Polylactic acid (PLA) is at present one of the most promising biodegradable polymers and has a wide range of applications. It has become one of the most important biomedical materials. But the PLA also has many disadvantages

which limits its application in the medicine field. In this paper

the strong hydrophobicity

poor cellular affinity

poor mechanical properties

aseptic inflammation reaction resulted from local accumulation of lactic acid produced by degradation products

lacking series products whose repair

degradation and absorption speed cannot well matched their cell proliferation and tissue repair speed

high cost

poor hole forming performance of homopolymer are reviewed. Summarized the scheme at home and abroad in recent years in view of the above various defects made

and the direction of research and development of PLA medical modification are discussed.Besides

the improvements made in recent years for each of the above defects are summarized. At last

the research and development orientation on PLA medical modification are prospected.