Fluorescent labeled silica has advantages of good biocompatibility

high luminescence intensity and stable performance. It is not only a good tracer material and drug carrier

but also an excellent reinforcing filler

which makes fluorescence-labeled silica been widely used in the fields of biological medicine and polymer composites. In order to achieve better fluorescent labeling effect

it is very important to select the appropriate fluorescent markers and labeling methods. In this paper

the synthesis and application of fluorescent silica were reviewed from the aspects of maker species selection

synthesis method and application research. And the future research direction and application prospect in biological medicine and polymer composites were also prospected.