Facing complex internal environment in human body

traditional medical adhesives have bad performance in binding tissues. Mussel-inspired adhesives have excellent underwater adhesion capability

which has arisen much attention on the application of such type of adhesives in the field of biomedical materials. Because dopamine has a similar structure and properties to the catechol in mussel protein

adhesives based on dopamine have been investigated widely. Firstly

the highly active phenolic hydroxyl groups in dopamine-based adhesives can adhere stably to the surface of tissues through covalent or non-covalent interactions. Secondly

the highly active phenolic hydroxyl group can also give adhesives superior cell affinity and cell adhesion. Dopamine-based adhesives can maintain the adhesion property underwater and have the characteristics of biocompatibility and cell adhesion. It can be seen that the addition of dopamine provides a larger room for developing tissue adhesives. This paper reviews the latest research progress of dopamine-based adhesives in the field of biomedical materials. According to the different ways of adding dopamine

the influencing factors of their adhesion strength and structure design are analyzed from two directions: functional hyperbranched polymer and linear polymerization of small molecules. Finally

existing problems and future development of dopamine-based adhesives are discussed.