纤维素基水凝胶研究进展

宁良允; 蒋军; 张代晖

doi:10.14028/j.cnki.1003-3726.2024.24.296

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纤维素基水凝胶研究进展

综述 | 更新时间：2025-01-06

- 纤维素基水凝胶研究进展
- Research Progress of Cellulose-based Hydrogels
- 高分子通报 2025年38卷第1期页码：41-57
- 作者机构：
  
  1.南京林业大学材料科学与工程学院，南京 210037
  2.中国林业科学研究院，林产化学工业研究所，国家林业和草原局林产化学工程重点实验室，江苏省生物质能源与材料重点实验室，南京 210042
- 作者简介：
  
  *蒋军，E-mail: jiangjun@njfu.edu.cn；张代晖，E-mail: dhzhang@icifp.cn
- 基金信息：
  
  国家自然科学基金(31901248);山东省科学院教育部重点实验室基金(KF202211)
- DOI：10.14028/j.cnki.1003-3726.2024.24.296
  中图分类号：
- 收稿日期：2024-10-06，
  
  录用日期：2024-11-10，
  
  网络出版日期：2024-12-03，
  
  纸质出版日期：2025-01-20
- 稿件说明：
移动端阅览
宁良允, 蒋军, 张代晖. 纤维素基水凝胶研究进展. 高分子通报, 2025, 38(1), 41–57.

Ning, L. Y.; Jiang, J. Zhang, D. H. Research progress of cellulose-ased hydrogels. Polym. Bull. (in Chinese), 2025, 38(1), 41–57.
宁良允, 蒋军, 张代晖. 纤维素基水凝胶研究进展. 高分子通报, 2025, 38(1), 41–57. DOI： 10.14028/j.cnki.1003-3726.2024.24.296.

Ning, L. Y.; Jiang, J. Zhang, D. H. Research progress of cellulose-ased hydrogels. Polym. Bull. (in Chinese), 2025, 38(1), 41–57. DOI： 10.14028/j.cnki.1003-3726.2024.24.296.

摘要

纤维素基水凝胶是一种基于天然高分子纤维素的三维网络亲水性聚合物，具有良好的生物相容性、高保水性、生物可降解性等特性。随着绿色低碳化发展理念的提出，可持续的天然聚合物材料已成为研究热点。纤维素基水凝胶作为天然聚合物的代表，在软材料领域备受关注。本文总结了纤维素基水凝胶的交联制备方法，主要有物理交联和化学交联。据此，介绍了纤维素基复合水凝胶在生物医药、柔性电子、食品工业、环境保护和生物工程等5个领域的功能化应用。随着研究不断深入，纤维素基水凝胶将在未来更多领域具备广阔的应用前景。

Abstract

Cellulose-based hydrogels are three-dimensional hydrophilic polymers derived from the natural polymer cellulose. They exhibit excellent biocompatibility

high water retention

and biodegradability. With the growing emphasis on green and low-carbon development

sustainable natural polymer materials have become a research hotspot. As a representative of natural polymers

cellulose-based hydrogels have garnered significant attention in the field of soft materials. This paper summarizes the preparation methods of cellulose-based hydrogels

which mainly include physical and chemical crosslinking. Also

we introduce the functional applications of cellulose-based composite hydrogels in five areas

including biomedicine

flexible electronics

food industry

environmental protection

and bioengineering. With the further development of the study

cellulose-based hydrogels are expected to possess broader applications in many fields in the future.

关键词

Keywords

references

Qiao, H. Y. ; Li, M. Y. ; Wang, C. Y. ; Zhang, Y. ; Zhou, H. M . Progress, challenge, and perspective of fabricating cellulose . Macromol. Rapid Commun. , 2022 , 43 ( 18 ), 2200208 .

Michelin, M. ; Gomes, D. G. ; Romaní, A. ; de Lourdes T M Polizeli, M. ; Teixeira, J. A . Nanocellulose production: exploring the enzymatic route and residues of pulp and paper industry . Molecules , 2020 , 25 ( 15 ), 3411 .

Hallac, B. B. ; Ragauskas, A. J . Analyzing cellulose degree of polymerization and its relevancy to cellulosic ethanol . Biofuels Bioprod. Biorefin. , 2011 , 5 ( 2 ), 215 – 225 .

Qi, Y. G. ; Guo, Y. Z. ; Liza, A. A. ; Yang, G. H. ; Sipponen, M. H. ; Guo, J. Q. ; Li, H. M . Nanocellulose: a review on preparation routes and applications in funct-ional materials . Cellulose , 2023 , 30 ( 7 ), 4115 – 4147 .

Szulc-Musioł, B. ; Siemiradzka, W. ; Dolińska, B . Formulation and evaluation of hydrogels based on sodium alginate and cellulose derivatives with quercetin for topical application . Appl. Sci. , 2023 , 13 ( 13 ), 7826 .

Zainal, S. H. ; Mohd, N. H. ; Suhaili, N. ; Anuar, F. H. ; Lazim, A. M. ; Othaman, R . Preparation of cellulose-based hydrogel: a review . J. Mater. Res. Technol. , 2021 , 10 , 935 – 952 .

Nicu, R. ; Ciolacu, F. ; Ciolacu, D. E . Advanced functional materials based on nanocellulose for pharmaceutical/medical applications . Pharmaceutics , 2021 , 13 ( 8 ), 1125 .

Divya, Chandra, P . Bioengineered cellulosic paper micro-device for serum albumin detection in clinical range . Int. J. Biol. Macromol. , 2024 , 258 , 128921 .

Liu, Y. L. ; Zhang, S. F. ; Li, L. ; Li, N . High-performance cellulose nanofibers/carbon nanotubes composite for constructing multifunctional sensors and wearable electronics . Adv. Fiber Mater. , 2024 , 6 ( 3 ), 758 – 771 .

Bao, Y. H. ; He, J. ; Song, K. ; Guo, J. ; Zhou, X. W. ; Liu, S. M . Functionalization and antibacterial applications of cellulose-based composite hydrogels . Polymers , 2022 , 14 ( 4 ), 769 .

Xu, Y. ; Liu, K. ; Yang, Y. F. ; Kim, M. S. ; Lee, C. H. ; Zhang, R. ; Xu, T. ; Choi, S. E. ; Si, C. L . Hemicellulose-based hydrogels for advanced applications . Front. Bioeng. Biotechnol. , 2023 , 10 , 1110004 .

Mehta, P. ; Sharma, M. ; Devi, M . Hydrogels: an overview of its classifications, properties, and applications . J. Mech. Behav. Biomed. Mater. , 2023 , 147 , 106145 .

Bremer-Sai, E. C. ; Yang, J. ; McGhee, A. ; Franck, C . Ballistic and blast-relevant, high-rate material properties of physically and chemically crosslinked hydrogels . Exp. Mech. , 2024 , 64 ( 4 ), 587 – 592 .

Hennink, W. E. ; van Nostrum, C. F . Novel crosslinking methods to design hydrogels . Adv. Drug Deliv. Rev. , 2012 , 64 , 223 – 236 .

Patel, D. K. ; Ganguly, K. ; Jin, H. X. ; Dutta, S. D. ; Patil, T. V. ; Lim, K. T . Functionalized chitosan/spherical nanocellulose-based hydrogel with superior antibacterial efficiency for wound healing . Carbohydr. Polym. , 2022 , 284 , 119202 .

Alven, S. ; Aderibigbe, B. A . Chitosan and cellulose-based hydrogels for wound management . Int. J. Mol. Sci. , 2020 , 21 ( 24 ), 9656 .

Li, Q. C. ; Tian, B. ; Tang, G. L. ; Zhan, H. Y. ; Liang, J. ; Guo, P. W. ; Liu, Q. ; Wu, W . Multifunctional conductive hydrogels for wearable sensors and supercapacitors . J. Mater. Chem. A , 2024 , 12 ( 6 ), 3589 – 3600 .

Su, T. ; Zhang, X. X. ; Wang, Z. R. ; Guo, Y. ; Wei, X. Y. ; Xu, B. ; Xia, H. T. ; Yang, W. Z. ; Xu, H . Cellulose nanocrystal-based polymer hydrogel embedded with iron oxide nanorods for efficient arsenic removal . Carbohydr. Polym. , 2024 , 331 , 121855 .

Saberi Riseh, R. ; Vatankhah, M. ; Hassanisaadi, M. ; Kennedy, J. F . Increasing the efficiency of agricultural fertilizers using cellulose nanofibrils: a review . Carbohydr Polym , 2023 , 321 , 121313 .

Li, P. ; Ling, Z. Y. ; Liu, X. Q. ; Bai, L. J. ; Wang, W. X. ; Chen, H. ; Yang, H. W. ; Yang, L. X. ; Wei, D. L . Nanocomposite hydrogels flexible sensors with functional cellulose nanocrystals for monitoring human motion and lactate in sweat . Chem. Eng. J. , 2023 , 466 , 143306 .

Fu, L. H. ; Qi, C. ; Ma, M, G. ; Wan, P, B . Multifunctional celluose-based hydrogels for boimedical applications . J. Mater. Chem. B. , 2019 , 7 , 1541 – 1562 .

Sekine, Y. ; Nankawa, T. ; Yunoki, S. ; Sugita, T. ; Nakagawa, H. ; Yamada, T . Eco-friendly carboxymethyl cellulose nanofiber hydrogels prepared via freeze cross-linking and their applications . ACS Appl. Polym. Mater. , 2020 , 2 ( 12 ), 5482 – 5491 .

Sekine, Y. ; Nankawa, T. ; Hiroi, K. ; Oba, Y. ; Nagakawa, Y. ; Sugita, T. ; Shibayama, Y. ; Ikeda-Fukazawa, T . Nanocellulose hydrogels formed via crystalline transformation from cellulose I to II and subsequent freeze cross-linking reaction . Carbohydr. Polym. , 2024 , 327 , 121538 .

Bustamante-Torres, M. ; Romero-Fierro, D. ; Arcentales-Vera, B. ; Palomino, K. ; Magaña, H. ; Bucio, E . Hydrogels classification according to the physical or chemical interactions and as stimuli-sensitive materials . Gels , 2021 , 7 ( 4 ), 182 .

Li, D. ; Liu, N. ; Yao, X. L. ; Gou, Q. X. ; Yue, J. X. ; Yang, D. ; Chen, X. Y. ; Xiao, M . Characterization of semi-interpenetrating hydrogel based on Artemisia sphaerocephala Krasch Polysaccharide and cellulose nanocrystals crosslinked by ferric ions . Food Hydrocoll. , 2023 , 139 , 108596 .

Lee, H. ; Hyun, J . Biophotovoltaic living hydrogel of an ion-crosslinked carboxymethylated cellulose nanofiber/alginate . Carbohydr. Polym. , 2023 , 321 , 121299 .

Chen, Z. P. ; Wei, Y. T. ; Liu, R. ; Hu, C. ; Sun, Y. Q. ; Yao, C. G. ; Wu, Z. L. ; Li, B. Z. ; Luo, Z. S. ; Huang, C. X . Sodium carboxymethyl cellulose hydrogels containing montmorillonite-NaClO 2 for postharvest preservation of Chinese bayberries . Food Chem. , 2024 , 454 , 139799 .

Tang, C. ; Zhao, B. ; Zhu, J. J. ; Lu, X. ; Jiang, G . Preparation and characterization of chitosan/sodium cellulose sulfate/silver nanoparticles composite films for wound dressing . Mater. Today Commun. , 2022 , 33 , 104192 .

Chen, Z. H. ; Zhao, X. ; Yu, Y. R. ; Zhou, J. P . Structure and properties of cellulose strengthened poly(acrylic acid) hydrogels . Macromol. Mater. Eng. , 2024 , 309 ( 9 ), 2300454 .

Zhao, T. ; Zhang, S. S. ; Bi, Y. T. ; Sun, D. ; Kong, F. G. ; Yuan, Z. W. ; Xin, X . Development and characterisation of multi-form composite materials based on silver nanoclusters and cellulose nanocrystals . Colloids Surf. A Physicochem. Eng. Aspects , 2020 , 603 , 125257 .

Lin, F. C. ; Wang, Z. ; Chen, J. S. ; Lu, B. L. ; Tang, L. R. ; Chen, X. R. ; Lin, C. S. ; Huang, B. ; Zeng, H. B. ; Chen, Y. D . A bioinspired hydrogen bond crosslink strategy toward toughening ultrastrong and multifunctional nanocomposite hydrogels . J. Mater. Chem. B , 2020 , 8 ( 18 ), 4002 – 4015 .

Varaprasad, K. ; Jayaramudu, T. ; Sadiku, E. R . Removal of dye by carboxymethyl cellulose, acrylamide and graphene oxide via a free radical polymerization process . Carbohydr. Polym. , 2017 , 164 , 186 – 194 .

Mendoza, D. J. ; Nasiri, N. ; Duffin, R. N. ; Raghuwanshi, V. S. ; Mata, J. ; Simon, G. P. ; Hooper, J. F. ; Garnier, G . Multifunctional graft-IPN hydrogels of cellulose nanofibers and poly( N -isopropyl acrylamide) via silver-promoted decarboxylative radical polymerization . Mater. Today Chem. , 2024 , 37 , 102014 .

More, A. P. ; Chapekar, S . Irradiation assisted synthesis of hydrogel: a review . Polym. Bull. , 2024 , 81 ( 7 ), 5839 – 5908 .

Masry, B. A. ; Gayed, H. M. ; Daoud, J. A . Gamma radiation synthesis of hydroxyethyl cellulose/acrylic acid/CYANEX 471X hydrogel for silver ions capture from acidic nitrate medium . Cellulose , 2024 , 31 ( 7 ), 4329 – 4346 .

Chen, Y. ; Yang, M. C. ; Zhang, W. W. ; Guo, W. H. ; Zhang, X. Q. ; Zhang, B. S . Facile preparation of irradiated poly(vinyl alcohol)/cellulose nanofiber hydrogels with ultrahigh mechanical properties for artificial joint cartilage . Materials , 2024 , 17 ( 16 ), 4125 .

Wang, R. ; Huang, X. B. ; Zoetebier, B. ; Dijkstra, P. J. ; Karperien, M . Enzymatic co-crosslinking of star-shaped poly(ethylene glycol) tyramine and hyaluronic acid tyramine conjugates provides elastic biocompatible and biodegradable hydrogels . Bioact. Mater. , 2023 , 20 , 53 – 63 .

Babaluei, M. ; Mojarab, Y. ; Mottaghitalab, F. ; Farokhi, M . Injectable hydrogel based on silk fibroin/carboxymethyl cellulose/agarose containing polydopamine functiona-lized graphene oxide with conductivity, hemostasis, antibacterial, and anti-oxidant properties for full-thickness burn healing . Int. J. Biol. Macromol. , 2023 , 249 , 126051 .

Dong, Y. Q. ; Zhao, S. W. ; Lu, W. H. ; Chen, N. ; Zhu, D. Y. ; Li, Y. C . Preparation and characterization of enzymatically cross-linked gelatin/cellulose nanocrystal composite hydrogels . RSC Adv. , 2021 , 11 ( 18 ), 10794 – 10803 .

Lee, D. ; Park, J. ; Hwang, K. ; Chun, S. J. ; Kim, J. H. ; Lee, T. J. ; Lee, B. T. ; Cho, H. J. ; Kim, B. J. ; Wu, Q. L. ; Gwon, J . Poly(vinyl alcohol) hydrogels reinforced with cellulose nanocrystals for sustained delivery of salicylic acid . ACS Appl. Nano Mater. , 2024 , 7 ( 4 ), 3918 – 3930 .

Hou, R. Q. ; Xie, Y. Y. ; Song, R. ; Bao, J. K. ; Shi, Z. Q. ; Xiong, C. X. ; Yang, Q. L . Nanocellulose/polypyrrole hydrogel scaffolds with mechanical strength and electrical activity matching native cardiac tissue for myocardial tissue engineering . Cellulose , 2024 , 31 ( 7 ), 4247 – 4262 .

Nypelö, T. ; Berke, B. ; Spirk, S. ; Sirviö, J. A . Review: periodate oxidation of wood polysaccharides-modu-lation of hierarchies . Carbohydr. Polym. , 2021 , 252 , 117105 .

Sun, Q. ; Dong, X. L. ; Xu, J. ; Wang, T . Silver-infused lysine crosslinked hydrogel with oxidized regenerated cellulose for prospective advanced wound dressings . Int. J. Biol. Macromol. , 2024 , 264 , 130675 .

Li, Y. ; Yao, M. Z. ; Luo, Y. D. ; Li, J. ; Wang, Z. L. ; Liang, C. ; Qin, C. R. ; Huang, C. X. ; Yao, S. Q . Polydopamine-reinforced hemicellulose-based multifunctional flexible hydrogels for human movement sensing and self-powered transdermal drug delivery . ACS Appl. Mater. Interfaces , 2023 , 15 ( 4 ), 5883 – 5896 .

Lin, J. Y. ; Zhang, Z. ; Lin, X. M. ; Cai, X. J. ; Fu, S. Y. ; Fang, X. ; Ding, Y. G. ; Wang, X. L. ; Sèbe, G. ; Zhou, G. F . All wood-based water evaporation-induced electricity generator . Adv. Funct. Mater. , 2024 , 34 ( 30 ), 2314231 .

Gao, J. L. ; Li, X. M. ; Xu, L. N. ; Yan, M. Q. ; Bi, H. ; Wang, Q. Y . Transparent multifunctional cellulose-based conductive hydrogel for wearable strain sensors and arrays . Carbohydr. Polym. , 2024 , 329 , 121784 .

Ma, Y. Y. ; Lu, Y. ; Yue, Y. Y. ; He, S. J. ; Jiang, S. H. ; Mei, C. T. ; Xu, X. W. ; Wu, Q. L. ; Xiao, H. N. ; Han, J. Q . Nanocellulose-mediated bilayer hydrogel actuators with thermo-responsive, shape memory and self-sensing performances . Carbohydr. Polym. , 2024 , 335 , 122067 .

Li, X. J. ; Zhang, Y. ; Chen, J. F. ; Wang, Y. N. ; Cheng, Z. Y. ; Chen, X. Q. ; Guo, M. H . A cellulose-based interpenetrating network hydrogel electrolyte for flexible solid-state supercapacitors . Cellulose , 2023 , 30 ( 4 ), 2399 – 2412 .

Lee, J. H. ; Nam, I. W. ; Hyun, J. E. ; Ahn, H. ; Yeo, S. Y. ; Lim, T . Conductive and robust cellulose hydrogel generated by liquid metal for biomedical applications . ACS Appl. Polym. Mater. , 2024 , 6 ( 1 ), 49 – 58 .

Shan, P. ; Wang, K. ; Sun, F. F. ; Li, Y. S. ; Sun, L. P. ; Li, H. ; Peng, L. C . Humidity-adjustable functional gelatin hydrogel/ethyl cellulose bilayer films for active food packaging application . Food Chem. , 2024 , 439 , 138202 .

Yu, K. J. ; Yang, L. N. ; Zhang, S. Y. ; Zhang, N. ; Wang, S. N. ; He, Y. T. ; Liu, H . Soy hull nanocellulose enhances the stretchability, transparency and ionic conductance of sodium alginate hydrogels and application in beef preservation . Food Hydrocoll. , 2024 , 152 , 109938 .

Yang, H. J. ; Li, L. P. ; Li, C. ; Xu, Z. H. ; Tao, Y. H. ; Lu, J. ; Xia, X. D. ; Tan, M. Q. ; Du, J. ; Wang, H. S . Multifunctional and antimicrobial carboxymethyl cellulose-based active hydrogel film for fruits packaging and preservation . Food Biosci. , 2024 , 59 , 104005 .

Chojnacka, K. ; Mikulewicz, M . Green analytical methods of metals determination in biosorption studies . Trac Trends Anal. Chem. , 2019 , 116 , 254 – 265 .

Zhang, H. M. ; Xue, K. ; Wang, B. ; Ren, W. F. ; Sun, D. ; Shao, C. Y. ; Sun, R. C . Advances in lignin-based biosorbents for sustainable wastewater treatment . Bioresour. Technol. , 2024 , 395 , 130347 .

Demirbilek, C. ; Dinç, C. Ö . Synthesis of diethylaminoethyl dextran hydrogel and its heavy metal ion adsorption characteristics . Carbohydr. Polym. , 2012 , 90 ( 2 ), 1159 – 1167 .

Zhao, B. C. ; Jiang, H. B. ; Lin, Z. K. ; Xu, S. F. ; Xie, J. ; Zhang, A. P . Preparation of acrylamide/acrylic acid cellulose hydrogels for the adsorption of heavy metal ions . Carbohydr. Polym. , 2019 , 224 , 115022 .

Hu, H. W. ; Chen, Z. W. ; Wang, C. X. ; Wang, L. F. ; Wang, X. ; Shi, Y. ; Chen, D . Two birds with one stone: An innovative fluorescent cellulose polyacrylamide-hydrogel modified by born/nitrogen-doped carbon dots with sensitive visual sensing and superior extraction capacity toward Ag + . Colloids Surf. A Physicochem. Eng. Aspects , 2024 , 684 , 133163 .

Lunardi, V. B. ; Santoso, S. P. ; Angkawijaya, A. E. ; Cheng, K. C. ; Tran-Nguyen, P. L. ; Go, A. W. ; Nakamura, Y. ; Lin, S. P. ; Hsu, H. Y. ; Yuliana, M. ; Soetaredjo, F. E. ; Ismadji, S . Synthesis of cellulose hydrogel by utilizing agricultural waste and zeolite for adsorption of copper metal ions . Ind. Crops Prod. , 2024 , 210 , 118179 .

Georgouvelas, D. ; Abdelhamid, H. N. ; Edlund, U. ; Mathew, A. P . In situ modified nanocellulose/alginate hydrogel composite beads for purifying mining effluents . Nanoscale Adv. , 2023 , 5 ( 21 ), 5892 – 5899 .

Fu, L. N. ; Li, Y. ; Zhang, X. L. ; Cui, J. H. ; Zhao, X. T. ; Wang, J. D. ; Zhou, Q. ; Wang, L. T. ; Fu, Y. J . Targeted recognition and enhanced biotransformation of phytochemicals by a dual-functional cellulose-based hydrogel bioreactor . Int. J. Biol. Macromol. , 2024 , 281 , 136271 .

Hedaiatnia, S. ; Ariaeenejad, S. ; Kumleh, H. H. ; Mirzaei, H. H. ; Shakeri, F. ; Motamedi, E . Lactic acid production enhancement using metagenome-derived bifunctional enzyme immobilized on chitosan-alginate/nanocellulose hydrogel . Bioresour. Technol. Rep. , 2024 , 25 , 101749 .

Zhang, H. ; Liu, W. B. ; Wang, L. ; Zhang, X. ; Wang, B. ; Zeng, X. ; Zhang, B . Functionalized corn stalk carboxymethyl cellulose and mesoporous silica SBA-15 composite hydrogel-immobilized lipase for the resolution of racemic ibuprofen ethyl ester . Green Chem. Lett. Rev. , 2024 , 17 ( 1 ), 2338241 .

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