面向浸没沉淀3D打印的聚己内酯/二甲基亚砜/水体系三元相图构建

高昂; 尹存宏; 张俊飞; 周欢; 郭蕊; 刘西霞

doi:10.14028/j.cnki.1003-3726.2025.24.398

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面向浸没沉淀3D打印的聚己内酯/二甲基亚砜/水体系三元相图构建

研究论文 | 更新时间：2025-04-29

- 面向浸没沉淀3D打印的聚己内酯/二甲基亚砜/水体系三元相图构建
- Construction of Ternary Phase Diagram of Polycaprolactone/Dimethyl Sulfoxide/Water System for Immersion Precipitation 3D Printing
- 高分子通报 2025年38卷第5期页码：790-800
- 作者机构：
  
  贵州大学机械工程学院，贵阳 550025
- 作者简介：
  
  *刘西霞，E-mail: xxliu@gzu.edu.cn
- 基金信息：
  
  贵州大学引进人才科研项目((2022)17号);贵州省基础研究(自然科学)青年引导项目(122)
- DOI：10.14028/j.cnki.1003-3726.2025.24.398
  中图分类号：
- 收稿日期：2024-12-31，
  
  录用日期：2025-01-27，
  
  网络出版日期：2025-03-17，
  
  纸质出版日期：2025-05-20
- 稿件说明：
移动端阅览
高昂, 尹存宏, 张俊飞, 周欢, 郭蕊, 刘西霞. 面向浸没沉淀3D打印的聚己内酯/二甲基亚砜/水体系三元相图构建. 高分子通报, 2025, 38(5), 790–800.

Gao, A.; Yi, C. H.; Zhang, J. F.; Zhou, H.; Guo, R.; Liu, X. X. Construction of ternary phase diagram of polycaprolactone/ dimethyl sulfoxide/ water system for immersion precipitation 3D printing. Polym. Bull. (in Chinese), 2025, 38(5), 790–800.
高昂, 尹存宏, 张俊飞, 周欢, 郭蕊, 刘西霞. 面向浸没沉淀3D打印的聚己内酯/二甲基亚砜/水体系三元相图构建. 高分子通报, 2025, 38(5), 790–800. DOI： 10.14028/j.cnki.1003-3726.2025.24.398.

Gao, A.; Yi, C. H.; Zhang, J. F.; Zhou, H.; Guo, R.; Liu, X. X. Construction of ternary phase diagram of polycaprolactone/ dimethyl sulfoxide/ water system for immersion precipitation 3D printing. Polym. Bull. (in Chinese), 2025, 38(5), 790–800. DOI： 10.14028/j.cnki.1003-3726.2025.24.398.

摘要

浸没沉淀3D打印技术能够实现复杂多孔结构的成形，广泛应用于生物医学领域，特别是在组织工程支架的制造中。该技术尤其适用于人体植入性聚己内酯

(PCL)支架的制备。制备多孔PCL结构的关键在于构建三元相图，通过分析浸没沉淀3D打印过程中的相分离成形机理，指导多孔结构形态的调控。但是，对于聚己内酯/二甲基亚砜/水(PCL/DMSO/H

O)三元体系的相分离成形机理的研究较少。因此，本研究旨在通过理论计算及实验测定，构建该体系的三元相图。基于Flory-Huggins理论，结合二元相互作用参数计算并绘制了双节线和旋节线。通过采用浊点滴定法获得浊点数据后绘制双节线，并与上述理论计算结果进行对比，验证了三元相图的正确性。基于构建的三元相图研究了浸没沉淀3D打印过程中的相分离成形机理，分析了不同PCL浓度对打印细丝微观形态的影响。结果表明，理论计算的双节线与实验测定的双节线吻合较好，随着PCL浓度的升高，细丝横截面微观形态变得愈加致密，孔隙率越来越小。

Abstract

Immersion precipitation 3D printing technology has been widely used in the biomedical field

owing to its facilitation of porous structure formation. For example

it is used in the manufacture of biodegradable polycaprolactone (PCL) scaffolds for human implants. The construction of a ternary phase diagram is key to preparing porous PCL structures and is also used to analyze the mechanisms of phase separation during the immersion precipitation 3D printing process

thereby guiding the regulation of the porous structural morphology. However

the phase separation mechanism of the polycaprolactone/dimethyl sulfoxide/water (PCL/DMSO/H

O) ternary system has rarely been studied. Therefore

this study aimed to construct a ternary phase diagram of the PCL/DMSO/H

O system through theoretical calculations and experimental measurements. Based on the Flory-Huggins theory and combined with the binary interaction parameter

the binodal and spinodal curves of the PCL/DMSO/H

O system were calculated and plotted. In addition

the binodal curve was plotted based on the cloud point data obtained using the cloud point titration method and compared with the theoretical calculations to validate the accuracy of the ternary phase diagram. Using the constructed ternary phase diagram

the formation mechanism of phase separation during the immersion precipitation 3D printing process was investigated

and the influence of different PCL concentrations on the microscopic morphology of the printed filaments was analyzed. The results indicate that the binodal curve derived from th

e theoretical calculations closely matches that obtained experimentally. As the PCL concentration increases

the microscopic morphology of the filament cross-section becomes denser

and the porosity decreases.

关键词

Keywords

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