分子间作用力“可视化”——高分子电解质模拟蛋白质神经元病变的科普实践

王璐雪; 朱洪良; 许兴燕; 刘小丽; 闫花妮; 宋艳华; 叶霖; 钟海政; 石建兵

doi:10.14028/j.cnki.1003-3726.2025.25.067

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分子间作用力“可视化”——高分子电解质模拟蛋白质神经元病变的科普实践

教育与教学 | 更新时间：2025-08-26

- 分子间作用力“可视化”——高分子电解质模拟蛋白质神经元病变的科普实践
- Visualization of Intermolecular Forces:——Popular Science Outreach on Simulating Protein Aggregation-induced Neurodegenerative Pathologies via Polyelectrolyte Models
- 高分子通报 2025年38卷第9期页码：1425-1432
- 作者机构：
  
  1.北京理工大学材料学院，北京 100081
  2.北京理工大学教育学院，北京 100081
  3.北京市大兴区兴华中学，北京 102600
  4.北京理工大学附属实验学校，北京 102400
- 作者简介：
  
  xlliu@bit.edu.cn
  bing@bit.edu.cn
- 基金信息：
  
  中国科协2024年度“翱翔之翼”大学生科技志愿服务项目(XMSB20240923022)
- DOI：10.14028/j.cnki.1003-3726.2025.25.067
  中图分类号：
- 收稿日期：2025-03-27，
  
  录用日期：2025-05-23，
  
  网络出版日期：2025-07-14，
  
  纸质出版日期：2025-09-20
- 稿件说明：
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王璐雪, 朱洪良, 许兴燕, 刘小丽, 闫花妮, 宋艳华, 叶霖, 钟海政, 石建兵. 分子间作用力“可视化”——高分子电解质模拟蛋白质神经元病变的科普实践[J]. 高分子通报, 2025,38(9):1425-1432.

WANG Lu-xue, ZHU Hong-liang, XU Xing-yan, LIU Xiao-li, YAN Hua-ni, SONG Yan-hua, YE Lin, ZHONG Hai-zheng, SHI Jian-bing. Visualization of Intermolecular Forces:——Popular Science Outreach on Simulating Protein Aggregation-induced Neurodegenerative Pathologies via Polyelectrolyte Models[J]. Polymer bulletin, 2025, 38(9): 1425-1432.
王璐雪, 朱洪良, 许兴燕, 刘小丽, 闫花妮, 宋艳华, 叶霖, 钟海政, 石建兵. 分子间作用力“可视化”——高分子电解质模拟蛋白质神经元病变的科普实践[J]. 高分子通报, 2025,38(9):1425-1432. DOI： 10.14028/j.cnki.1003-3726.2025.25.067.

WANG Lu-xue, ZHU Hong-liang, XU Xing-yan, LIU Xiao-li, YAN Hua-ni, SONG Yan-hua, YE Lin, ZHONG Hai-zheng, SHI Jian-bing. Visualization of Intermolecular Forces:——Popular Science Outreach on Simulating Protein Aggregation-induced Neurodegenerative Pathologies via Polyelectrolyte Models[J]. Polymer bulletin, 2025, 38(9): 1425-1432. DOI： 10.14028/j.cnki.1003-3726.2025.25.067.

摘要

利用高分子电解质阴、阳离子间的强分子间作用力，模拟神经退行性疾病中蛋白质间的不同聚集状态，演示分子间作用力在聚集体形成过程中的调控机制，帮助大、中、小学生群体理解神经退行性疾病的发病原理，激发他们的科学兴趣。相比于使用真实发病过程中的蛋白质，该科普实验使用的高分子电解质具有成本低、易操作等优点，且分子间作用力更强，能够更直观、快速地展示出分子间作用力与发病机制的关系，具有可操作、易普及的特点。此外，该科普实验设计简单、现象明显，利于中小学教师实验准备、课堂演示，更有利于学生动手实践、思维拓展等科学素质的培养。

Abstract

Strong intermolecular force between anionic polyelectrolytes and cationic polyelectrolytes was used to simulate different aggregation states between proteins in neurodegenerative diseases

and the regulatory mechanism of intermolecular force in the formation of aggregates was demonstrated. It aims to help students in primary

middle and high school understand the pathogenesis of neurodegenerative diseases and stimulate their scientific interest. Compared with proteins in the real pathogenesis process

the polyelectrolyte used in this popular science experiment has the advantages of low cost

easy operation

and stronger intermolecular interaction. All these characteristics can display the relationship between intermolecular force and pathogenesis more intuitively and quickly

which has the features of being operable and easy to be popularized. In addition

the design of this popular experiment is simple and the phenomenon is obvious

which is conducive to the experiment preparation and classroom demonstration of primary

middle and high school teachers. moreover

this popularization of science is more beneficial to the cultivation of students’ scientific qualities such as hands-on practice and thinking expansion.

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references

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