Advance of Drug-loaded Micelles Based on Amphiphilic Copolymer Self-assembly

Xiang-mei WANG; Xiao-li ZHANG; Han-gen CHEN

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Advance of Drug-loaded Micelles Based on Amphiphilic Copolymer Self-assembly

更新时间：2022-09-18

- Advance of Drug-loaded Micelles Based on Amphiphilic Copolymer Self-assembly
- Polymer Bulletin Vol. 26, Issue 7, Pages: 27-32(2013)
- 作者机构：
  
  1.中北大学化工与环境学院，太原　030051
  2.中北大学理学院，太原　030051
- 作者简介：
- 基金信息：
- DOI：
  CLC：
- Published：2013-07，
  
  Received：15 January 2013，
  
  Revised：16 March 2013，
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Xiang-mei WANG, Xiao-li ZHANG, Han-gen CHEN. Advance of Drug-loaded Micelles Based on Amphiphilic Copolymer Self-assembly. [J]. Polymer Bulletin 26(7):27-32(2013)
DOI：

Xiang-mei WANG, Xiao-li ZHANG, Han-gen CHEN. Advance of Drug-loaded Micelles Based on Amphiphilic Copolymer Self-assembly. [J]. Polymer Bulletin 26(7):27-32(2013) DOI：

摘要

两亲聚合物胶束具有突出的理化性能和独特功能

能够在溶液中自组形成具有核壳结构的聚合物胶束

同时实现药物的负载。自组装包药技术能够缓解我国药物辅料缺乏的现状

符合目前药物辅料发展的新趋势。通过自组装形成的聚合物胶束在药物控释、药物靶向载体、药物制剂开发、新型药物辅料等方面具有广阔的应用前景。本文综述了两亲聚合物胶束自组装包载药物的原理以及方法

重点介绍了三类两亲聚合物在自组装包药方面的最新研究成果和发展趋势。本文还对载药胶束在药物释放方面的应用进行了概述。

Abstract

Amphiphilic polymer micelles had prominent physical and chemical features and-particular function

which could form polymeric micelles with a core-shell structure and achieved drug-loaded by self-assembly in solution. The technology of self-assembly drug-loaded can alleviate the lack of drug materialsin China and meet the new trend of drug excipients.Polymeric micelles formed by self-assembly technology has intensive prospect in targeting drug delivery

developing pharmaceutical formulations and new drug materials. The principles and methods of drug-loaded micelles were summarized

especially the latest research achievements and the future development of three types of amphiphilic polymer micelles in self-assembly carry drug. Meanwhile

the applications of drug-loaded micelles in drug release were summarized in this paper.

关键词

两亲聚合物胶束自组装载药

Keywords

Amphiphilic polymerMicellesSelf-assemblyDrug-loaded

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