The Preparation of <italic style="font-style: italic">O</italic>-CMC Magnetic Nanoparticles Having Tafreted and Anticancer Function

Xiao-jin ZHANG; Xu-bo YUAN; Yun-xia HU; Jin CHANG; Chun-sheng KANG; Pei-yu PU

doi:10.14028/j.cnki.1003-3726.2004.03.013

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The Preparation of O-CMC Magnetic Nanoparticles Having Tafreted and Anticancer Function

更新时间：2022-09-18

- The Preparation of O-CMC Magnetic Nanoparticles Having Tafreted and Anticancer Function
- Polymer Bulletin Vol. 17, Issue 3, Pages: 89-92,98(2004)
- 作者机构：
  
  1.天津大学材料学院纳米生物技术研究所，天津　3000072
  2.天津医科大学，天津　300052
- 作者简介：
- 基金信息：
- DOI：10.14028/j.cnki.1003-3726.2004.03.013
  CLC：
- Published：2004-06，
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Xiao-jin ZHANG, Xu-bo YUAN, Yun-xia HU, Jin CHANG, Chun-sheng KANG, Pei-yu PU. The Preparation of O-CMC Magnetic Nanoparticles Having Tafreted and Anticancer Function. [J]. Polymer Bulletin 17(3):89-92,98(2004)
DOI：

Xiao-jin ZHANG, Xu-bo YUAN, Yun-xia HU, Jin CHANG, Chun-sheng KANG, Pei-yu PU. The Preparation of O-CMC Magnetic Nanoparticles Having Tafreted and Anticancer Function. [J]. Polymer Bulletin 17(3):89-92,98(2004) DOI： 10.14028/j.cnki.1003-3726.2004.03.013.

摘要

首次以

-羧甲基壳聚糖（

-CMC）为原料，制备出具有超顺磁特性的正电性纳米载体，并将其与抗癌药物甲氨喋呤（MTX）结合，构建成平均粒径50nm 的具有磁靶向抗癌功能的纳米载体系统。该载体在人体血液微循环模型进行的体外靶向定位试验中呈现良好的磁感应性。体外抑瘤试验结果表明，该磁性纳米载药体系中MTX 保持了较好的抗肿瘤特性。

Abstract

-CMC Magnetic nanoparticles were prepared by a method of co-precipitation with O-CMC matrix.The MTX was linked to the

-CMC Magnetic nanoparticles with EDC method.The nanoparticlces with average diameters of 50nm were obtained and characterized by TEM

AFM and VSM.Meanwhile

more than 95% of

-CMC nanoparticles accumulated under the1T external magnet field in a model of simulated blood circulation in human capillary vessels.The cytotoxicity of MTX loaded

-CMC magnetic narloparticles was investigated with U-937 tumor cells.The results showed that the MTX loaded

-CMC magnetic nanoparticles remained the significant antitumor toxicity and sustained release of MTX from

-CMC nanoparticles was observed in vitro.

关键词

O-羧甲基壳聚糖甲氨喋呤药物载体系统肿瘤治疗磁性纳米颗粒

Keywords

O-Carboxymethylated chitosanMTXDrug delivery systemMagnetic nanoparticlesCancer therapy

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The Preparation of O-CMC Magnetic Nanoparticles Having Tafreted and Anticancer Function

DOI：10.14028/j.cnki.1003-3726.2004.03.013

摘要

Abstract

关键词

Keywords

references