The Degradation and Release Behavior of 5-Fluorouracil-loaded PLGA/<italic style="font-style: italic">O</italic>-CMC Nanoparticles in vitro

Yun-xia HU; Jin CHANG; Yi GUO; Chun-sheng KANG; Xu-bo YUAN; Cun-xia SONG

doi:10.14028/j.cnki.1003-3726.2004.05.009

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The Degradation and Release Behavior of 5-Fluorouracil-loaded PLGA/O-CMC Nanoparticles in vitro

更新时间：2022-09-18

- The Degradation and Release Behavior of 5-Fluorouracil-loaded PLGA/O-CMC Nanoparticles in vitro
- Polymer Bulletin Vol. 17, Issue 5, Pages: 62-68(2004)
- 作者机构：
  
  a.天津大学材料科学与工程学院纳米生物技术研究所，天津　300072
  b.中国医学科学院生物医学工程研究所，天津　300192
- 作者简介：
- 基金信息：
- DOI：10.14028/j.cnki.1003-3726.2004.05.009
  CLC：
- Published：2004-10，
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Yun-xia HU, Jin CHANG, Yi GUO, Chun-sheng KANG, Xu-bo YUAN, Cun-xia SONG. The Degradation and Release Behavior of 5-Fluorouracil-loaded PLGA/O-CMC Nanoparticles in vitro. [J]. Polymer Bulletin 17(5):62-68(2004)
DOI：

Yun-xia HU, Jin CHANG, Yi GUO, Chun-sheng KANG, Xu-bo YUAN, Cun-xia SONG. The Degradation and Release Behavior of 5-Fluorouracil-loaded PLGA/O-CMC Nanoparticles in vitro. [J]. Polymer Bulletin 17(5):62-68(2004) DOI： 10.14028/j.cnki.1003-3726.2004.05.009.

摘要

本文以聚乳酸-乙醇酸共聚物(PLGA)和自行制备的

-羧甲基壳聚糖(

-CMC)为原料，以5-氟尿嘧啶(5-FU)为抗癌药物模型，采用自身设计的改良复乳法制备了载药纳米微粒。微粒平均粒径为98.5nm，粒径分布指数为0.192，粒子表面ξ电位为61.48eV，载药率高达18.9%，包封率为86%。然后用SEM 动态监测载药纳米粒子降解过程中表面形貌的变化，并连续追踪粒子降解过程中的质量损失和降解介质的pH 变化。载药纳米粒子在PBS 中的释药行为研究表明：(1)前12h 的释药动力学符合Huguchi 方程，具有一级释放特性；(2)在20天内的释药动力学符合零级释放特性。

Abstract

Due to the attractive biodegradation and physicochemical properties

poly (D

L-lactide-coglycolic acid) (PLGA)and

-carboxymethyl chitosan(

-CMC) were chosen to microencapsulate 5-fluorouracil (5-FU) by improved W/O/W method.The mean size of the resulting5-FU-loaded nanoparticles (NPs) was 98.5nm with fine polydispersity (0.192) and high Zeta potential (61.48eV).The drug-loading level and encapsulation efficiency of the NPs were 18.9% and 86%

respectively.SEM was used to study the morphological change of NPs during the degradation;and the weight loss of NPs and pH change of degradation medium were traced as well.The investigation of 5-FU release behavior from NPs showed that(1) the release kinetics of5-FU from NPs in early12hours was coincided with Hugucbi release equation;(2)the release kinetics in20days was coincided with Zero-level release.

关键词

O-羧甲基壳聚糖聚乳酸-乙醇酸共聚物纳米微粒抗癌药物

Keywords

O-Carboxymethylated chitosan(O-CMC)Poly (DL-lactide-co-glycolic acid) (PLGA)Nanoparticles(NPs)Anticancer drug

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The Degradation and Release Behavior of 5-Fluorouracil-loaded PLGA/O-CMC Nanoparticles in vitro

DOI：10.14028/j.cnki.1003-3726.2004.05.009

摘要

Abstract

关键词

Keywords

references