The immunonanoparticle [HILE6-PLA(5-Fu)-NP] was prepared by "EDC" method crosslinking the monoclonal antibody HILE6with PLA nanoparticles containing 5-Fu [PLA(5-Fu)-NP].The particles were characterized for morphology and structure by scanning electronic microscopy (SEM) and transmission electronic microscopy (TEM).The particle size was determined by Particle Size Analyzer.5-Fu drug content was also examined.ELISA method was used to evaluate the immunoreactivity.The indirect immunofluorescence method was used for evaluation of the selectivity of the INPs.We found NPs have smooth external morphology and the particle size was 191∙0 ± 0∙202 nm

the drug loading was 8∙2%.In the immunonanoparticles

the immunological activity of antibody can reach84% of the original HILE6.HILE6-PLA(5-Fu)-NP could bind the lens epithelia specifically.The result is very beneficial for selectively and longtime killed Lens epithelia cells for preventing posterior capsular opacification.