Advance in the Study of Chitosan and its Derivatives as Non-Viral Vectors

Jin HUANG; Shi-long WANG; Xiao-yu SUN; Wen-zhe LI; Si-de YAO

doi:10.14028/j.cnki.1003-3726.2006.01.010

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Advance in the Study of Chitosan and its Derivatives as Non-Viral Vectors

更新时间：2022-09-18

- Advance in the Study of Chitosan and its Derivatives as Non-Viral Vectors
- Polymer Bulletin Vol. 19, Issue 1, Pages: 65-69(2006)
- 作者机构：
  
  同济大学生命科学与技术学院，上海　200092
- 作者简介：
- 基金信息：
- DOI：10.14028/j.cnki.1003-3726.2006.01.010
  CLC：
- Published：2006-01，
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Jin HUANG, Shi-long WANG, Xiao-yu SUN, Wen-zhe LI, Si-de YAO. Advance in the Study of Chitosan and its Derivatives as Non-Viral Vectors. [J]. Polymer Bulletin 19(1):65-69(2006)
DOI：

Jin HUANG, Shi-long WANG, Xiao-yu SUN, Wen-zhe LI, Si-de YAO. Advance in the Study of Chitosan and its Derivatives as Non-Viral Vectors. [J]. Polymer Bulletin 19(1):65-69(2006) DOI： 10.14028/j.cnki.1003-3726.2006.01.010.

摘要

壳聚糖是一种天然的生物可降解性，生物相容性好而且安全无毒的多糖，因而它成为基因治疗载体研究的热点。本文就近年来壳聚糖及其衍生物作为基因载体转染的研究进展和现状作简要的综述，并对转染率的影响因素如壳聚糖的分子量、粒径、脱乙酰度等进行着重介绍。

Abstract

Recently chitosan is focused in the research of gene delivery system for it is already known as a biocompatible

biodegradable and non-toxic polysaccharide.This article is to summarize the recent development of chitosan and its derivatives as non-viral vectors for gene transfection.And the influential factors of the transfection efficiency are also discussed such as molecular mass of chitosan

size of chitosan nanoparticle and depolymerization of chitosan.

关键词

壳聚糖纳米粒非病毒载体转染率

Keywords

ChitosanNanoparticleNon-viral vectorTransfection efficiency

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