Preparation of Alkyl-chitosan Nanoparticles and its Application as a Carrier System for Paclitaxel

Zhao DAI; Duo-xian SUN; Weng-qiang HUANG

doi:10.14028/j.cnki.1003-3726.2006.06.008

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Preparation of Alkyl-chitosan Nanoparticles and its Application as a Carrier System for Paclitaxel

更新时间：2022-09-18

- Preparation of Alkyl-chitosan Nanoparticles and its Application as a Carrier System for Paclitaxel
- Polymer Bulletin Vol. 19, Issue 6, Pages: 64-67,74(2006)
- 作者机构：
  
  1.功能高分子材料教育部重点实验室，南开大学；南开大学高分子化学研究所，天津　300071；
  2.天津大学化工学院，天津　300072
- 作者简介：
- 基金信息：
- DOI：10.14028/j.cnki.1003-3726.2006.06.008
  CLC：
- Published：2006-06，
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Zhao DAI, Duo-xian SUN, Weng-qiang HUANG. Preparation of Alkyl-chitosan Nanoparticles and its Application as a Carrier System for Paclitaxel. [J]. Polymer Bulletin 19(6):64-67,74(2006)
DOI：

Zhao DAI, Duo-xian SUN, Weng-qiang HUANG. Preparation of Alkyl-chitosan Nanoparticles and its Application as a Carrier System for Paclitaxel. [J]. Polymer Bulletin 19(6):64-67,74(2006) DOI： 10.14028/j.cnki.1003-3726.2006.06.008.

摘要

在碱性条件下通过卤代烃的

-烷基取代反应制备得到烷基壳聚糖衍生物。X 射线光电子能谱计算结果表明烷基取代反应主要发生在壳聚糖的氨基上。动态光散射研究表明，该衍生物在水中可自动形成粒径在10～ 200nm 范围的纳米微粒，负载紫杉醇后微球的粒径增大，在磷酸缓冲液（pH =7.4）中体外释放研究表明，随着烷基链长的增加，紫杉醇在磷酸缓冲液中达到平衡时的浓度降低。

Abstract

Alkyl-chitosan

modified chemically by alkyl halide under alkaline condition

is soluble and spontaneously forms nanoparticles about 10-200 nm in diameters by Dynamic light scattering (DLS) .It was found by X-ray photoelectron spectroscopy (XPS) that the alkyl substitution reaction was mainly on amine groups of chitosan . After carrying paclitaxel

the sizes of the particles of alkyl-chitosan were larger than before .In phosphate buffer solution (PBS

pH =7.4)

the vitro release rate of paclitaxel from this system was delayed

and the equilibration release concentration of paclitaxel was deceased by the increase of carbon chain length in alkyl substituted chitosan .

关键词

壳聚糖烷基壳聚糖紫杉醇纳米微球负载和释放

Keywords

ChitosanAlkyl-chitosanNanoparticlesPaclitaxelPaclitaxel drug delivery

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