Secure and efficient gene carrier is a prerequisite of gene therapy coming into reality.Cationic polymer is an important kind of non-viral gene carriers because it is easily produced and modified at a large scale

has no immunogenecity

can complex DNA into compact microparticle to prevent degradation of DNA from Dnase and carry DNA into cell.But cationic polymer has acute cytotoxicity related to charge and lower transfection efficiency than viral carrier

which limits its use in clinical gene therapy.Here

research progress on cationic polymeric gene carrier was summarized in enhancing transfection efficiency and decreasing cytotoxicity.Eight measures of improving cationic polymeric gene carrier in transfection were summaried and the development of cationic polymeric gene carrier was forcast.