Thermosensitive Polyphosphazenes and its Applications in Drug-Delivery

Shuang WU

doi:10.14028/j.cnki.1003-3726.2007.09.004

您当前的位置：

首页 >

文章列表页 >

Thermosensitive Polyphosphazenes and its Applications in Drug-Delivery

更新时间：2022-09-18

- Thermosensitive Polyphosphazenes and its Applications in Drug-Delivery
- Polymer Bulletin Vol. 20, Issue 9, Pages: 31-38(2007)
- 作者机构：
  
  辽宁石油化工大学石油化工学院，抚顺　113001
- 作者简介：
- 基金信息：
- DOI：10.14028/j.cnki.1003-3726.2007.09.004
  CLC：
- Published：2007-09，
扫描看全文
Shuang WU. Thermosensitive Polyphosphazenes and its Applications in Drug-Delivery. [J]. Polymer Bulletin 20(9):31-38(2007)
DOI：

Shuang WU. Thermosensitive Polyphosphazenes and its Applications in Drug-Delivery. [J]. Polymer Bulletin 20(9):31-38(2007) DOI： 10.14028/j.cnki.1003-3726.2007.09.004.

摘要

温敏性聚合物能通过感知温度而实现环境响应，作为药剂可依靠对此类信号的自反馈响应而释放药物或中止释放，极大地增强了释药的持续性和专一性，从而提高了药物的药效和安全性。温敏性聚膦腈是一类新型的温敏材料，它具有良好的生物可降解性质，优良的生物相容性。因此，温敏性聚膦腈作为药物载体用于药物释放体系具有很好的应用前景，近年来备受关注。本文对聚膦腈的温敏性质、生物降解性质进行了评述，并探讨了LCST 的影响因素，以及在药物释放体系的应用进展。

Abstract

Thermosensitive polymers applying in drug preparations have been greatly increasing effectiveness and safety of drugs due to their enhanced continuity and specificity in drug-delivery

since they can release or break off drug component depending on the self-feedback signal that is induced in response to environmental temperature. Thermosensitive polyphosphazenes that are a novel material with good biodegradability and excellent biocompatibility have attracted considerable attention recently because of their promising potential applications in the development of drug delivery systems. In this article thermosensitivity and biodegradability of polyphosphazenes are reviewed. The influence of LCST of polyphosphazenes and their applications in drug delivery systems are also discussed.

关键词

聚膦腈温敏性生物降解性低临界溶解温度药物释放

Keywords

PolyphosphazenesThermosensitivityBiodegradationLow critical solution temperatureDrugdelivery

references

更多指标>

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Advances in Injectable Thermosensitive Polymers

New Type of Biodegradable Polymer Used in Medical —— Polyphosphazenes

Newly Advances in Thermosensitive Hydrogel

Related Author

No data

Related Institution

Research Institute of Polymeric Materials, Tianjin University

Interventional Radiology Division of Shandong Medical Imaging Research Institute

School of Chemical Engineering and Technology, Tianjin University

School of Polymer Science and Engineering,Qingdao University of Science and Technology

⁰