Application of PNIPA Nano-hydrogels for Controlled and Sustained Drug Release

Jian ZHANG; Hai-yan CHEN; Yue-qing GU

doi:10.14028/j.cnki.1003-3726.2007.10.005

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Application of PNIPA Nano-hydrogels for Controlled and Sustained Drug Release

更新时间：2022-09-18

- Application of PNIPA Nano-hydrogels for Controlled and Sustained Drug Release
- Polymer Bulletin Vol. 20, Issue 10, Pages: 52-56(2007)
- 作者机构：
  
  中国药科大学生命科学与技术学院，南京　210038
- 作者简介：
- 基金信息：
- DOI：10.14028/j.cnki.1003-3726.2007.10.005
  CLC：
- Published：2007-10，
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Jian ZHANG, Hai-yan CHEN, Yue-qing GU. Application of PNIPA Nano-hydrogels for Controlled and Sustained Drug Release. [J]. Polymer Bulletin 20(10):52-56(2007)
DOI：

Jian ZHANG, Hai-yan CHEN, Yue-qing GU. Application of PNIPA Nano-hydrogels for Controlled and Sustained Drug Release. [J]. Polymer Bulletin 20(10):52-56(2007) DOI： 10.14028/j.cnki.1003-3726.2007.10.005.

摘要

简要介绍了聚N-异丙基丙烯酰胺（Poly N-isopropylacrylamide，PNIPA）类纳米水凝胶的性质及智能响应机理，并重点综述了近年来此类纳米水凝胶在药物缓控释研究中的应用：作为脂溶性小分子药物的载体，达到增溶及缓控释药物的效果，并增强药物的稳定性及生物活性；作为水溶性小分子药物的载体，达到缓释该类药物的效果；作为生物大分子药物（蛋白，多糖）的载体，克服直接用药时的弊端；此外，还可作为基因工程载体。

Abstract

In this article

the properties and the responsive mechanism of PNIPA nano-hydrogels were briefly introduced. And then more emphasis was placed on the application of PNIPA nano-hydrogels as drug carriers for controlled and sustained drug release. They provide liposoluble drugs with stability

solubility

bioactivity. And hydrosoluble drugs entrapped in PNIPA nano-hydrogels can be sustainedly released. They can also be used as carriers for biomacromolecule drugs to avoid disadvantage in application. PNIPA nano-hydrogels are also favourable gene engineering carriers.

关键词

PNIPA纳米水凝胶温敏性缓释控释

Keywords

PNIPANano-hydrogelThermosensitiveSustained releaseControlled release

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