Recent Advances in the Anti-infection Induced by Polymer Medical Material Implants

Chun-yan LI; Li SHAN; Duan-yan CHU; Jian-hua HUANG; Zhi-guo WEN; Sheng-xiong DONG

doi:10.14028/j.cnki.1003-3726.2009.11.010

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Recent Advances in the Anti-infection Induced by Polymer Medical Material Implants

更新时间：2022-09-18

- Recent Advances in the Anti-infection Induced by Polymer Medical Material Implants
- Polymer Bulletin Vol. 22, Issue 11, Pages: 57-61(2009)
- 作者机构：
  
  1.∙福建医科大学药学院，福州　350108
  2.∙福州大学化学化工学院，福州　350108
- 作者简介：
- 基金信息：
- DOI：10.14028/j.cnki.1003-3726.2009.11.010
  CLC：
- Published：2009-11，
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Chun-yan LI, Li SHAN, Duan-yan CHU, Jian-hua HUANG, Zhi-guo WEN, Sheng-xiong DONG. Recent Advances in the Anti-infection Induced by Polymer Medical Material Implants. [J]. Polymer Bulletin 22(11):57-61(2009)
DOI：

Chun-yan LI, Li SHAN, Duan-yan CHU, Jian-hua HUANG, Zhi-guo WEN, Sheng-xiong DONG. Recent Advances in the Anti-infection Induced by Polymer Medical Material Implants. [J]. Polymer Bulletin 22(11):57-61(2009) DOI： 10.14028/j.cnki.1003-3726.2009.11.010.

摘要

植入式高分子医用材料表面会粘附细菌形成生物膜引发生物材料相关的感染（BRI），给高分子医用材料的广泛应用提出了重大挑战。本文从BRI 发生的机制入手，综述了通过高分子医用材料表面改性减少细菌粘附与使用抗菌素-生物材料体系两个方面来抵抗BRI 发生的研究进展，重点阐述了局部抗菌药物缓释体系及纳米技术在抗菌药物缓释体系中的应用，并指出高分子前药控释体系的研究和应用是抗高分子医用材料感染的发展趋势。

Abstract

The surface of polymer medical material implants adsorbs bacteria to form biofilm lead to biomaterial related infection (BRI) represent a significant challenge to the application of polymer medical material. This paper introduced BRI mechanism

summarized the research of surface modification to reduce bacterial adhesion and antibacterial-biomaterial system. The recent advances of these two methods resistant the occurrence of BRI. Emphasize on local antibacterial sustained-release system and the application of nanotechnology in antibacterial sustained-release system. The research and application of polymer prodrug controlled-release system is the tendency of anti-infective polymer medical material.

关键词

高分子医用材料抗感染表面改性抗菌药物缓释体系高分子前药控释体系

Keywords

Polymer medical materialAnti-infectionSurface modificationAntibacterial sustained-release systemPolymer prodrug controlled-release system

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