Polymeric Drugs And Carrier Materials

Jun-lian WANG; Hong HAO; Yang WANG; Tao ZHAO; Xiao-yu GUAN; Kai WANG

doi:10.14028/j.cnki.1003-3726.2011.01.009

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Polymeric Drugs And Carrier Materials

更新时间：2022-09-18

- Polymeric Drugs And Carrier Materials
- Polymer Bulletin Vol. 24, Issue 1, Pages: 59-64(2011)
- 作者机构：
  
  西北大学化工学院，西安　710069
- 作者简介：
- 基金信息：
- DOI：10.14028/j.cnki.1003-3726.2011.01.009
  CLC：
- Published：2011-01，
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Jun-lian WANG, Hong HAO, Yang WANG, Tao ZHAO, Xiao-yu GUAN, Kai WANG. Polymeric Drugs And Carrier Materials. [J]. Polymer Bulletin 24(1):59-64(2011)
DOI：

Jun-lian WANG, Hong HAO, Yang WANG, Tao ZHAO, Xiao-yu GUAN, Kai WANG. Polymeric Drugs And Carrier Materials. [J]. Polymer Bulletin 24(1):59-64(2011) DOI： 10.14028/j.cnki.1003-3726.2011.01.009.

摘要

高分子药物由于具有良好的生物降解性和生物相容性

可以控制药物释放速度

能够降低药物的毒副作用

减少抗药性

提高药物的稳定性和有效利用率

从而引起国内外广泛关注。本文从自身具有药理活性的高分子、高分子载体药物两个方面综述了近年来高分子药物及载体材料的研究进展。按化学结合力不同将高分子载体药物分为高分子前药和高分子络合物药物。相对原游离药物

高分子载体可以显著优化其药动学和药效学性质。除此之外

对该领域的研究前景和和所面临的问题也进行了探讨。

Abstract

Polymeric drug has good biodegradability and biocompatinbility.It can be used to control the drug release rate

reduce the toxic side effects and drug resistance

and enhance the stability and effective utilization rate.This article reviews recent research progress of polymers with pharmacological activity and polymeric carrier meterials.Polymeric carrier materials are classified in accordance with chemical combining power as polymeric prodrug and polymeric complex.Comparing with the original free drugs

polymeric carriers can optimize free drugs qualities of pharmacokinetics and pharmacodynamics.At last

the research prospects and the problems in this domain are discussed.

关键词

高分子药物前药络合物药理活性

Keywords

Polymeric drugProdrugComplexPharmacological activity

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Related Institution

Research and Development Center of Carbon Based Synthetic Materials of Huayang Group

Institute of Molecular Medicine, Ministry of Education,Huaqiao University

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