The Preparation of Chitosan Microspheres and Appl ication in Biology and Medicine

Ting YANG; Wen-long HOU; Yue-dong YANG

doi:10.14028/j.cnki.1003-3726.2011.05.011

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The Preparation of Chitosan Microspheres and Appl ication in Biology and Medicine

更新时间：2022-09-18

- The Preparation of Chitosan Microspheres and Appl ication in Biology and Medicine
- Polymer Bulletin Vol. 24, Issue 5, Pages: 51-56(2011)
- 作者机构：
  
  河北科技师范学院理化学院，秦皇岛　066004
- 作者简介：
- 基金信息：
- DOI：10.14028/j.cnki.1003-3726.2011.05.011
  CLC：
- Published：2011-05，
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Ting YANG, Wen-long HOU, Yue-dong YANG. The Preparation of Chitosan Microspheres and Appl ication in Biology and Medicine. [J]. Polymer Bulletin 24(5):51-56(2011)
DOI：

Ting YANG, Wen-long HOU, Yue-dong YANG. The Preparation of Chitosan Microspheres and Appl ication in Biology and Medicine. [J]. Polymer Bulletin 24(5):51-56(2011) DOI： 10.14028/j.cnki.1003-3726.2011.05.011.

摘要

壳聚糖是唯一天然碱性氨基多糖

它具有良好的生物相容性、低毒性和生物可降解性

是制备微球的良好材料。本文综述了近年来国内外壳聚糖微球的制备方法

如喷雾干燥法、乳化交联法、逐层自组装法、界面聚合法、溶剂蒸发法以及离子凝胶法

分析了不同制备方法的优点及不足。壳聚糖微球不仅可作为固定化酶或细胞的载体

而且是一种具有广泛应用前景的新型药物载体

本文还对壳聚糖微球在固定化酶或细胞和包埋药物领域的应用进行了概述。

Abstract

Chitosan is the only natural occurring basic poly saccharide containing amino groups

which shows favorable biocompatibility

low-toxicity

biological degradability

and is suitable for preparing micro spheres. In this paper

the preparation methods of chitosan micro spheres are reviewed

which include spray drying

emulsion crosslinking

layer-by-lay er self-assembly

interfacial polyme rization

solvent evapo ration and ionotropic gelation method. The advantages and disadvantages of different methods are discussed. Chitosan microspheres can immobili zed enzyme or cells

and has wide prospect in application for carrier drugs. The application of chitosan micro spheres in immobilized enzyme or cells and embedding drugs is also reviewed.

关键词

壳聚糖微球生物医药应用

Keywords

ChitosanMicrospheresBiology and medicineApplication

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