Progress in MRI Contrast Agent Ligands Modified by Macromolecules

Sheng-bin LIANG; Fei CHANG; Jian-qi LI; Xin-xin LI; Chun-mei SONG

doi:10.14028/j.cnki.1003-3726.2011.07.015

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Progress in MRI Contrast Agent Ligands Modified by Macromolecules

更新时间：2022-09-18

- Progress in MRI Contrast Agent Ligands Modified by Macromolecules
- Polymer Bulletin Vol. 24, Issue 7, Pages: 96-102(2011)
- 作者机构：
  
  1.化学系　华东师范大学，上海　200062，
  2.上海市磁共振重点实验室，华东师范大学，上海　200062，
  3.华东理工大学材料学院，上海　200237
- 作者简介：
- 基金信息：
- DOI：10.14028/j.cnki.1003-3726.2011.07.015
  CLC：
- Published：2011-07，
  
  Received：14 September 2010，
  
  Revised：28 October 2010，
扫描看全文
Sheng-bin LIANG, Fei CHANG, Jian-qi LI, Xin-xin LI, Chun-mei SONG. Progress in MRI Contrast Agent Ligands Modified by Macromolecules. [J]. Polymer Bulletin 24(7):96-102(2011)
DOI：

Sheng-bin LIANG, Fei CHANG, Jian-qi LI, Xin-xin LI, Chun-mei SONG. Progress in MRI Contrast Agent Ligands Modified by Macromolecules. [J]. Polymer Bulletin 24(7):96-102(2011) DOI： 10.14028/j.cnki.1003-3726.2011.07.015.

摘要

磁共振成像造影剂是一种信号增强剂

在临床上已有广泛应用。本文介绍了磁共振造影剂配体的种类、结构、改性研究情况和发展趋势

并通过弛豫理论解释合成大分子配体的原因。将含有大分子、靶向性、天然大分子、荧光探针的配体与顺磁性金属Gd（Ⅲ）螯合

制得功能磁共振造影剂

可有效增加弛豫效果和降低生物毒性。

Abstract

Magnetic resonance imaging (MRI) contrast agents are used widely in clinical use.The advantage of macromolecular contrast agents was explained by relaxation theory.The chemical structures and development of the contrast agents were also introduced in this review. The paramagnetic Gadolinium (Ⅲ) chelates were modified by synthetic polymers

naturally occurring polymers

targeted agents and fluorescent labeled agents.It is indicated that the specific effects of modified contrast agents such as targeting and florescent labeled would raise the relaxation rate and reduce the toxicity.

关键词

造影剂磁共振弛豫理论荧光探针大分子配体靶向性

Keywords

Contrast agentsMagnetic resonance imaging (MRI)Relaxation theoryFluorescent labeledMacromolecular ligandsTargeted agents

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