Modification and Clinical Application of Hyaluronic Acid

Ya-ho ng CAO; Ho ng HAO; Xiong-xiong WEI; Jian-guo LIANG; Cheng HUANG

doi:10.14028/j.cnki.1003-3726.2011.12.003

您当前的位置：

首页 >

文章列表页 >

Modification and Clinical Application of Hyaluronic Acid

更新时间：2022-09-18

- Modification and Clinical Application of Hyaluronic Acid
- Polymer Bulletin Vol. 24, Issue 12, Pages: 50-55(2011)
- 作者机构：
  
  1.西北大学化工学院，西安　710069
  2.湖南大学化学与化工学院，长沙　410082
- 作者简介：
- 基金信息：
- DOI：10.14028/j.cnki.1003-3726.2011.12.003
  CLC：
- Published：2011-12，
  
  Received：10 January 2011，
  
  Revised：22 April 2011，
扫描看全文
Ya-ho ng CAO, Ho ng HAO, Xiong-xiong WEI, Jian-guo LIANG, Cheng HUANG. Modification and Clinical Application of Hyaluronic Acid. [J]. Polymer Bulletin 24(12):50-55(2011)
DOI：

Ya-ho ng CAO, Ho ng HAO, Xiong-xiong WEI, Jian-guo LIANG, Cheng HUANG. Modification and Clinical Application of Hyaluronic Acid. [J]. Polymer Bulletin 24(12):50-55(2011) DOI： 10.14028/j.cnki.1003-3726.2011.12.003.

摘要

透明质酸具有极高的保湿性、粘弹性、润滑性、生物相容性和生物降解性

在医药、组织工程及临床医学中得到广泛应用。但天然HA 稳定性差

对强酸、强碱、热及透明质酸酶敏感等缺陷限制了其在临床上的应用

因此改性HA 的研究越来越受到关注。本文综述了近年来国内外采用交联、酯化、复合/ 共聚等方法对HA的改性研究

介绍了H A 及衍生物在眼科手术、声外科手术、骨关节炎治疗、防术后粘连和药物输送系统等临床应用情况

并对其发展前景进行展望。

Abstract

Hyaluronic acid is widely used for medical field

tissue engineering and clinical medicine due to its excellent moisture retention

viscoelasticity

lubricity

biocompatibility and biodegradability. The unstability and sensitivity of natural HA to strong acid

base

heat and hyaluronidase limit its clinical application

so the research on modificated HA has been paid more attention. This review concentrates on the recent research achievement on the preparation of HA derivatives by corss-linking

esterification

composition and copolymerization

as well as their clinical application especially in ophthalmic surgery

phonosurgery

osteoarthritis treatment and drug delivery system.

关键词

透明质酸改性生物相容性生物降解性临床应用

Keywords

Hyaluronic acid ( HA)ModificationBiocompatibilityBiodegradabilityClinical application

references

更多指标>

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Research Progress of Poly (butylene succinate)

Structures and Properties of Polyimide Materials for Membrane-based Gas Separation

Research Progress in Preparation of Modified Natural Polymer Flocculants

Recent Progress on Bacterial Cellulose

Synthesis and Modification of Aramid

Related Author

No data

Related Institution

Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of Ministry of Education, College of Chemistry & Materials Science,Northwest University

State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, University of Chinese Academy of Sciences, Chinese Academy of Sciences

School of Chemical Engineering, Chinese Academy of Sciences University

Chemistry and Environmental Engineering, Yangtze University

Key Laboratory of Oil and Gas Fine Chemicals, Ministry of Education, School of Chemistry Engineering,Xinjiang University

⁰