Advances of Natural Macromolecular Cell Culture Matrix

Shi-he LONG; Ming-sheng LI; Dong-wu JIN; Zhong-ren MA; Yu-ping FENG

doi:10.14028/j.cnki.1003-3726.2015.02.006

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Advances of Natural Macromolecular Cell Culture Matrix

更新时间：2022-09-18

- Advances of Natural Macromolecular Cell Culture Matrix
- Polymer Bulletin Vol. 28, Issue 2, Pages: 40-46(2015)
- 作者机构：
  
  1.西北民族大学生物工程与技术国家民委重点实验室，兰州　730030
  2.甘肃省动物细胞工程技术研究中心，兰州　730030
  3.西北民族大学生命科学与工程学院，兰州　730030
- 作者简介：
- 基金信息：
- DOI：10.14028/j.cnki.1003-3726.2015.02.006
  CLC：
- Published：2015-02，
  
  Received：07 May 2014，
  
  Revised：16 October 2014，
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Shi-he LONG, Ming-sheng LI, Dong-wu JIN, Zhong-ren MA, Yu-ping FENG. Advances of Natural Macromolecular Cell Culture Matrix. [J]. Polymer Bulletin 28(2):40-46(2015)
DOI：

Shi-he LONG, Ming-sheng LI, Dong-wu JIN, Zhong-ren MA, Yu-ping FENG. Advances of Natural Macromolecular Cell Culture Matrix. [J]. Polymer Bulletin 28(2):40-46(2015) DOI： 10.14028/j.cnki.1003-3726.2015.02.006.

摘要

天然高分子材料如壳聚糖、丝素蛋白和胶原蛋白等具有异体抗原性弱、生物相容性好、可生物降解且能促进细胞粘附、生长和增殖等优点.同人工合成高分子材料相比

天然高分子几乎不含有机溶剂和引发剂等物质

生物安全性高

是细胞培养基质的首选原材料.近年来

随着生物科技的发展

其新功能也不断被发现并受到学术界的广泛重视.本文综述了天然多糖类和天然蛋白质类高分子材料的理化性质及在细胞培养基质领域中的应用

对目前所存在的一些问题进行了描述并预测其发展动向。

Abstract

Materials in natural polymers have weak allograft antigenicity

good compatibility and biodegradable and can promote cell adhesion

growth and proliferation

Such as chitosan

silk fibroin and collagen. Compare to synthetic polymer

the natural polymers almost do not contain organic solvent and initiators. It showed high biological safety and is preferential to use in cell culture matrix raw materials. In recent years

along with the development of biotechnology

new functions of these natural polymer are being found and valued. In this paper

the physical and chemical properties of natural polysaccharide and protein as well as their application as cell culture matrix are reviewed in details

and the existing problems were described and the development directions of these materials was forecasted.

关键词

天然高分子生物相容性细胞培养基质

Keywords

Natural polymersBiocompatibilityCell culture matrix

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