Dendriner polyamide amine (PAMAM) is a new three-dimensional polymer material which possesses properties of controlled particle size

monodispersion

non-immunogenicity

low cytotoxicity and biodegradation. As drug carriers

it has some advantages of small size

high permeability and retention (EPR) effect

good stability

high drug loading and so on

which can actively target specific tissues

cells or some certain targets through modification of targeting molecules

to improve therapeutic effect and decrease toxicity. The advantages and the latest research progress of active targeting PAMAM drug delivery system (ATPDDS) as drug active delivery platform is reviewed.