Preparation of Maleoyl Chitosan Nanoparticles by Self-Assembly and their pH Responsability

Xue JIANG; Xiao-qing WANG; Huai-jun CHEN; Ji-dong HE

doi:10.14028/j.cnki.1003-3726.2015.04.007

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Preparation of Maleoyl Chitosan Nanoparticles by Self-Assembly and their pH Responsability

更新时间：2022-09-18

- Preparation of Maleoyl Chitosan Nanoparticles by Self-Assembly and their pH Responsability
- Polymer Bulletin Vol. 28, Issue 4, Pages: 59-66(2015)
- 作者机构：
  
  青岛科技大学，橡塑材料与工程教育部重点实验室/山东省橡塑材料与工程重点实验室，青岛　266042
- 作者简介：
- 基金信息：
- DOI：10.14028/j.cnki.1003-3726.2015.04.007
  CLC：
- Published：2015-04，
  
  Received：15 April 2014，
  
  Revised：07 November 2014，
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Xue JIANG, Xiao-qing WANG, Huai-jun CHEN, Ji-dong HE. Preparation of Maleoyl Chitosan Nanoparticles by Self-Assembly and their pH Responsability. [J]. Polymer Bulletin 28(4):59-66(2015)
DOI：

Xue JIANG, Xiao-qing WANG, Huai-jun CHEN, Ji-dong HE. Preparation of Maleoyl Chitosan Nanoparticles by Self-Assembly and their pH Responsability. [J]. Polymer Bulletin 28(4):59-66(2015) DOI： 10.14028/j.cnki.1003-3726.2015.04.007.

摘要

采用碳酸钠为催化剂

室温下制备了水溶性的马来酰化壳聚糖

研究了反应物投料比对酰化取代度以及产物水溶性的影响。红外光谱结果说明马来酸酐成功接枝到壳聚糖分子上;XRD结果说明马来酸酐酰化破坏了壳聚糖分子内和分子间的氢键作用

使水溶性大大提高。用Nano-ZS90 Malvern仪器对不同pH值下的粒子粒径和Zeta电位进行测定

发现存在1个等电点:pH = 3.01。文章首次采用自组装方法分别在醋酸、甲酸、乳酸溶液中制备得到三种不同的马来酰化壳聚糖纳米粒子并用SEM做了表征;DLS测试表明

当pH值增大后

三种纳米粒子粒径均由几十纳米溶胀到几百纳米

显示具有pH响应性。

Abstract

The maleoyl chitosan (MCS) was prepared at room temperature by using sodium carbonate as catalyst. The effect of reactant feed ratio on the degree of substitution and water-solubility of acylated product was studied. FT-IR show that the maleic anhydride is successfully grafted onto chitosan molecule

X-ray diffractometry(XRD) results indicate that maleic anhydride acylating destructed the hydrogen bonds within and between molecules of chitosan

which greatly improved water-solubility. The particle size and zeta potential at different pH values were determined by using Nano-ZS90 Malvern Instruments. The isoelectric point is pH = 3. 01. Three different maleoyl Chitosan nanoparticles in acetic acid

formic acid

lactic acid solution were prepared by self-assembly approach for the first time

which were characterized by scanning electron microscopy(SEM). Dynamic light scattering(DLS) tests show that three kinds of nanoparticles swelled from tens of nanometers to hundreds of nanometers when the pH value increased

which displays the pH-responsive property.

关键词

壳聚糖自组装纳米粒子pH响应性药物释放

Keywords

ChitosanSelf-assemblyNanoparticlespH- ResponsiveDrug delivery

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