Synthese of Temperature and pH Dual Responsive Nano Micelles Based on Poly (L-Glutamic Acid) and the Drug Release Profile

Qi-yi YANG; Ming LIU; Lin XI; Lei TAO; Jun TAN; Gang SHI; Cai-hua NI

doi:10.14028/j.cnki.1003-3726.2015.08.009

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Synthese of Temperature and pH Dual Responsive Nano Micelles Based on Poly (L-Glutamic Acid) and the Drug Release Profile

更新时间：2022-09-18

- Synthese of Temperature and pH Dual Responsive Nano Micelles Based on Poly (L-Glutamic Acid) and the Drug Release Profile
- Polymer Bulletin Vol. 28, Issue 8, Pages: 69-76(2015)
- 作者机构：
  
  江南大学食品胶体与生物技术教育部重点实验室，江南大学化学与材料工程学院，无锡　214122
- 作者简介：
- 基金信息：
- DOI：10.14028/j.cnki.1003-3726.2015.08.009
  CLC：
- Published：2015-08，
  
  Received：08 December 2014，
  
  Revised：11 February 2015，
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Qi-yi YANG, Ming LIU, Lin XI, Lei TAO, Jun TAN, Gang SHI, Cai-hua NI. Synthese of Temperature and pH Dual Responsive Nano Micelles Based on Poly (L-Glutamic Acid) and the Drug Release Profile. [J]. Polymer Bulletin 28(8):69-76(2015)
DOI：

Qi-yi YANG, Ming LIU, Lin XI, Lei TAO, Jun TAN, Gang SHI, Cai-hua NI. Synthese of Temperature and pH Dual Responsive Nano Micelles Based on Poly (L-Glutamic Acid) and the Drug Release Profile. [J]. Polymer Bulletin 28(8):69-76(2015) DOI： 10.14028/j.cnki.1003-3726.2015.08.009.

摘要

首先制备端氨基聚（

-异丙基丙烯酰胺-

-聚乙二醇）大分子引发剂，再通过端氨基引发

-谷氨酸-

-苄酯-

-羧酸酐开环聚合，制备了聚（

-异丙基丙烯酰胺-

-聚乙二醇）与聚（

-谷氨酸-

-苄酯）的嵌段共聚物，将其中的y-苄酯基团转化为酰肼基团后与阿霉素(DOX)共价结合，最后在水溶液中自组装成纳米胶束，制备了温度和pH值双重响应性纳米胶束。胶束外层由亲水性聚（

-异丙基丙烯酰胺-

-聚乙二醇）组成，具有温敏性，低临界溶液温度为38℃ ；胶束内层由聚（

-谷氨酸-

-酰肼-阿霉素）组成。该胶束对于药物的释放具有温度和pH双重敏感性。

Abstract

Poly(

-isopropylacrylamide-

-polyethylene glycol)-b-poly(

-glutamic acid-

-benzyl ester) was synthesized by ring opening polymerization of

-carboxyl anhydride of

-benzyl-

-glutamate (NCA) using the amino terminal macromolecule as an initiator. The y-benzyl ester groups in side chain were converted into hydrazide by hydrazine hydrate. Doxorubicin (DOX) was covalently loaded on the terpolymer

yielding nano micelles with DOX-loaded poly (

-glutamic hydrazide) as the core

and poly(

-isopropylacrylamide-

-poly ethylene glycol) as the hydrophilic shell. The micelles could be used as a drug carrier

showing temperature and pH dual responsive behaviors.

关键词

L-谷氨酸N-异丙基丙烯酰胺阿霉素胶束腙键

Keywords

L-glutamic acidN-isopropylacrylamideDOXMicellesHydrazine

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