Proteins

as the material basis of life

must fold and assembled property into precise three-dimensional conformations to maintain their physiological activity

and to fulfill their normal biological functions. Once misfolding and abnormal aggregation

proteins will not only lose their biological activity

but also lead to a number of serious diseases

such as Alzheimer's disease

Parkinson's disease

Huntington's disease and some types of cancers

which are terrible threaten to human life and health. Therefore

how to effectively regulate protein folding has become one of the most challenging problems in life sciences. On the basis of a brief introduction of protein folding mechanism

we reviewed the recent progress in the development of protein folding control strategy

discussed the methods based on nanomaterials in detail and finally proposed the development trend of this field.