Recent Develpoment of Angiogenesis Promoting Substance in Tissue Engineering

Ying-xue ZHANG; We WANG; Zhi YUAN

doi:10.14028/j.cnki.1003-3726.2015.09.013

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Recent Develpoment of Angiogenesis Promoting Substance in Tissue Engineering

更新时间：2022-09-18

- Recent Develpoment of Angiogenesis Promoting Substance in Tissue Engineering
- Polymer Bulletin Vol. 28, Issue 9, Pages: 187-197(2015)
- 作者机构：
  
  功能高分子材料教育部重点实验室，南开大学高分子化学研究所，　天津市化学化工协同创新中心，天津　300071
- 作者简介：
- 基金信息：
- DOI：10.14028/j.cnki.1003-3726.2015.09.013
  CLC：
- Published：2015-09，
  
  Received：20 June 2015，
  
  Revised：05 July 2015，
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Ying-xue ZHANG, We WANG, Zhi YUAN. Recent Develpoment of Angiogenesis Promoting Substance in Tissue Engineering. [J]. Polymer Bulletin 28(9):187-197(2015)
DOI：

Ying-xue ZHANG, We WANG, Zhi YUAN. Recent Develpoment of Angiogenesis Promoting Substance in Tissue Engineering. [J]. Polymer Bulletin 28(9):187-197(2015) DOI： 10.14028/j.cnki.1003-3726.2015.09.013.

摘要

组织工程是一门将细胞生物学和材料科学相结合，在体外或体内人工构建组织或器官的新兴学科。在厚组织工程研究中，如何在支架材料中构建血管网络，从而为新生组织提供必要的氧气养分已成为目前研究的热点。在促血管化的研究中，生长因子与粘附性多肽两类活性物质应用最为广泛，其中生长因子主要包括血管内皮生长因子(VEGF)、血管生成素-l(Ang-l)、血管生成素-2（Ang-2)、血小板衍生生长因子(PDGF)、碱性成纤维细胞生长因子(bFGF)等；粘附性多肽主要包括精氨酸-甘氨酸-天冬氨酸(RGD)、精氨酸-谷氨酸-天冬氨酸-缬氨酸(REDV)、酪氨酸-异亮氨酸-甘氨酸-丝氨酸-精氨酸(YIGSR)等。本文对这两类物质在组织工程，尤其是在促进血管新生方面的研究进行了综述。

Abstract

Tissue engineering is a new discipline which combines biology and material science to construct tissue or organs in vitro or in vivo. In the study of promoting angiogenesis

growth factors and adhesion peptides

these two kinds of material have a wide range of applications. Growth factors includes vascular endothelial growth factor (VEGF) and angiopoietin 1 (Ang-1)

angiopoietin-2 (Ang-2)

platelet derived growth factor (PDGF) and basic fibroblast growth factor (bFGF) ; adhesion peptide mainly includes Arg-Gly-Asp (RGD)

Ary-Glu-Asp-Val (REDV) and Tyr-Ile-Gly-Ser-Arg (YIGSR). This paper summarizes the research progress of these two kinds of materials in tissue engineering.

关键词

组织工程促血管化生长因子粘附性多肽

Keywords

Tissue engineeringAngiogenesisGrowth factorAdhesive peptide

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Related Institution

Jiangsu Key Laboratory of Biofunctional Materials, College of Chemistry and Materials Science, Nanjing Normal University

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Department of Polymer Materials,School of Materials Science and Engineering,Shanghai University

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