Review of Hyaluronan : its Structure, Properties, Modifications and Applications

Kun ZHANG; Jun JIAN; Zheng-pu ZHANG

doi:10.14028/j.cnki.1003-3726.2015.09.016

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Review of Hyaluronan : its Structure, Properties, Modifications and Applications

更新时间：2022-09-18

- Review of Hyaluronan : its Structure, Properties, Modifications and Applications
- Polymer Bulletin Vol. 28, Issue 9, Pages: 217-226(2015)
- 作者机构：
  
  1.生物可降解新材料北京市工程实验室，北京　100022
  2.南开大学高分子化学研究所，天津　300071
- 作者简介：
- 基金信息：
- DOI：10.14028/j.cnki.1003-3726.2015.09.016
  CLC：
- Published：2015-09，
  
  Received：09 June 2015，
  
  Revised：30 June 2015，
扫描看全文
Kun ZHANG, Jun JIAN, Zheng-pu ZHANG. Review of Hyaluronan : its Structure, Properties, Modifications and Applications. [J]. Polymer Bulletin 28(9):217-226(2015)
DOI：

Kun ZHANG, Jun JIAN, Zheng-pu ZHANG. Review of Hyaluronan : its Structure, Properties, Modifications and Applications. [J]. Polymer Bulletin 28(9):217-226(2015) DOI： 10.14028/j.cnki.1003-3726.2015.09.016.

摘要

透明质酸是天然存在的一种具有高黏弹性、高保湿性的大分子糖胺聚糖，被广泛用作各种生物医用材料，如眼科手术助剂、手术后防粘连剂、皮肤填充剂、药物载体、组织工程支架等。为赋予透明质酸更为优良的机械强度、流变学特性及抗酶解能力，扩大其在生物医学领域的应用范围，越来越多的改性透明质酸衍生物被设计开发。本文对透明质酸的结构、性能、改性、应用进行了综述。

Abstract

Hyaluronan is a naturally existing high molecular weight glycosaminoglycan with high viscoelasticity and moisture retention

which has been widely used in numerous medical applications

such as ophthalmologic surgery

anti- adhesion application

dermal filling

and drug delivery system. More and more hyaluronan derivatives have been designed and developed in order to improving its mechanical strength

rheological property

enzyme resistant ability and other properties to extend its biomedical application range. In this review

we summarized the chemical structure

properties

modifications and applications of hyaluronan with the purpose of providing help and guidance for the future research.

关键词

透明质酸化学改性生物医学

Keywords

HyaluronanChemical modificationBiomedical applications

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