Research Progress on the Interactions of Biomaterial Surfaces/Interfaces with Proteins and Cells

Qian YU; Xiao-li LIU; Zhong-lin LYU; Lei WANG; Xiu-juan SHI; Xin LI; Hong CHEN

doi:10.14028/j.cnki.1003-3726.2015.10.001

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Research Progress on the Interactions of Biomaterial Surfaces/Interfaces with Proteins and Cells

更新时间：2022-09-18

- Research Progress on the Interactions of Biomaterial Surfaces/Interfaces with Proteins and Cells
- Polymer Bulletin Vol. 28, Issue 10, Pages: 1-8(2015)
- 作者机构：
  
  苏州大学材料与化学化工学部，苏州　215123
- 作者简介：
- 基金信息：
- DOI：10.14028/j.cnki.1003-3726.2015.10.001
  CLC：
- Published：2015-10，
  
  Received：10 June 2015，
  
  Revised：15 June 2015，
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Qian YU, Xiao-li LIU, Zhong-lin LYU, Lei WANG, Xiu-juan SHI, Xin LI, Hong CHEN. Research Progress on the Interactions of Biomaterial Surfaces/Interfaces with Proteins and Cells. [J]. Polymer Bulletin 28(10):1-8(2015)
DOI：

Qian YU, Xiao-li LIU, Zhong-lin LYU, Lei WANG, Xiu-juan SHI, Xin LI, Hong CHEN. Research Progress on the Interactions of Biomaterial Surfaces/Interfaces with Proteins and Cells. [J]. Polymer Bulletin 28(10):1-8(2015) DOI： 10.14028/j.cnki.1003-3726.2015.10.001.

摘要

材料接触生物环境首先是通过其界面

这种材料界面与生物环境中的生物分子及细胞之间的相互作用决定着材料生物功能的实现。因此

调控材料与生物体的界面相互作用几乎是所有生物材料的研究及应用首先和必然面对的关键共性问题。本文综述了近年来我们课题组在生物表界面领域的研究及其最新进展。从分子层面上设计生物功能表面入手

建立了一系列普适、高效、简单易行的表面功能化新方法用于改变材料表面的物理化学性质

进而调控材料表面与蛋白质或细胞/细菌之间的相互作用。

Abstract

Materials contact with biological systems through their surfaces/interfaces; the interaction of material surfaces with the biomolecules and cells in the biological environment plays an important role to determine the realization of the biological functionalities of the materials. Therefore

the regulation of the interactions between the materials and the organism is the key issue in the research and application of biomaterials. In this review

we summarized the recent research progress of our group in the field of biointerfaces. Based on the design of biofunctional surfaces on the molecular level

we have established a series of facile modification methods with high efficiency and general applicability to change the physical and chemical properties of material surfaces

and thus to regulate the interactions of material surfaces with a variety of biological molecules(such as proteins)or cells/bacteria.

关键词

生物材料表界面蛋白质细胞细菌相互作用

Keywords

Biomaterial surfaces/interfacesProteinCellBacteriaInteraction

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