The Synthesis and Characterization of Copolyanhydride via Solid-Liquid Phase Transfer Catalysis

Fu-quan LI; Li YAN

doi:10.14028/j.cnki.1003-3726.2015.11.007

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The Synthesis and Characterization of Copolyanhydride via Solid-Liquid Phase Transfer Catalysis

更新时间：2022-09-18

- The Synthesis and Characterization of Copolyanhydride via Solid-Liquid Phase Transfer Catalysis
- Polymer Bulletin Vol. 28, Issue 11, Pages: 50-55(2015)
- 作者机构：
  
  1.呼和浩特民族学院，呼和浩特　010050
  2.华北理工大学　材料科学与工程学院，唐山　063009
- 作者简介：
- 基金信息：
- DOI：10.14028/j.cnki.1003-3726.2015.11.007
  CLC：
- Published：2015-11，
  
  Received：03 January 2015，
  
  Revised：05 May 2015，
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Fu-quan LI, Li YAN. The Synthesis and Characterization of Copolyanhydride via Solid-Liquid Phase Transfer Catalysis. [J]. Polymer Bulletin 28(11):50-55(2015)
DOI：

Fu-quan LI, Li YAN. The Synthesis and Characterization of Copolyanhydride via Solid-Liquid Phase Transfer Catalysis. [J]. Polymer Bulletin 28(11):50-55(2015) DOI： 10.14028/j.cnki.1003-3726.2015.11.007.

摘要

采用18-冠-6(18C6)为相转移催化剂

制备了一系列不同单体比例的聚共聚酸酐P(CPP-SA)

并优化了聚合反应条件.P(CPP-SA)化学结构由傅里叶红外光谱(FT-IR)和核磁共振氢谱(

H-NMR)表征

并通过特征黏度计算了P(CPP-SA)的黏均分子量.结果表明最佳的反应条件是18C6的用量20%

反应时间15h

P(CPP-SA)特征黏度可达到1.2dL/g

黏均分子量为2.02×10

.将P(CPP-SA)置于pH=7.4的磷酸缓冲溶液中进行体外降解

结果表明

降解率与CPP/SA比例有关

其中P(CPP-SA)(CPP/SA=50/50mol/mol)的共聚酸酐降解率与降解时间接近线性关系

具有较好的应用前景。

Abstract

A series of poly copolymers(P(CPP-SA))with different monomer proportions were synthesized via solid-liquid phase transfer catalytic method using 18-crown-6(18C6) as catalyst. The structures of P(CPP-SA)s were characterized by FT-IR and

H-NMR methods. The viscosity-average molecular weights of P(CPP-SA)s were calculated though the intrinsic viscosities. The reaction conditions were investigated that using 20% 18C6 after 15h the intrinsic viscosity of P(CPP-SA) reached to 1.2dL/g with the viscosity-average molecular weight was 2.02×10

. The in-vitro degradation tests of P(CPP-SA)s were carried out in phosphate buffer solution (pH=7.4). The results indicated that the degradation ratioes depended on the monomer proportions. When the CPP/SA was 50/50 (mol/mol)

the linear relationship between degradation ratio and degradation time was verified. The application of P(CPP-SA)(CPP/SA=50/50) was well promising.

关键词

共聚酸酐相转移体外降解

Keywords

CopolyanhydridePhase transferDegradation in vitro

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