A Review of Smart Hydrogel for 3D Cell Culture

Dan-dan MA; Ke HU; Xiao-e MA; Nai-zhen ZHOU; Ning GU; Tian-zhu ZHANG

doi:10.14028/j.cnki.1003-3726.2015.12.006

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A Review of Smart Hydrogel for 3D Cell Culture

更新时间：2022-09-18

- A Review of Smart Hydrogel for 3D Cell Culture
- Polymer Bulletin Vol. 28, Issue 12, Pages: 47-53(2015)
- 作者机构：
  
  东南大学生物科学与医学工程学院，江苏省生物材料与器件重点实验室，南京　210009
- 作者简介：
- 基金信息：
- DOI：10.14028/j.cnki.1003-3726.2015.12.006
  CLC：
- Published：2015-12，
  
  Received：29 November 2014，
  
  Revised：02 June 2015，
扫描看全文
Dan-dan MA, Ke HU, Xiao-e MA, Nai-zhen ZHOU, Ning GU, Tian-zhu ZHANG. A Review of Smart Hydrogel for 3D Cell Culture. [J]. Polymer Bulletin 28(12):47-53(2015)
DOI：

Dan-dan MA, Ke HU, Xiao-e MA, Nai-zhen ZHOU, Ning GU, Tian-zhu ZHANG. A Review of Smart Hydrogel for 3D Cell Culture. [J]. Polymer Bulletin 28(12):47-53(2015) DOI： 10.14028/j.cnki.1003-3726.2015.12.006.

摘要

与传统的体外二维细胞培养(2D培养)相比

体外三维细胞培养(3D培养)因能更好地模拟细胞外基质(ECM)而备受关注。智能水凝胶不仅具有良好的生物相容性

其特殊的结构性能能有效模拟细胞外基质

实现细胞3D培养

而且通过智能凝胶简单的响应性

可以改变细胞生长的微环境

实现在三维空间内对细胞进行特异性的培养和研究。本文基于智能凝胶和细胞3D培养

综述了智能凝胶的类型、在细胞3D培养中的应用

以及智能凝胶对细胞生长和行为的影响。

Abstract

Compared with the traditional two-dimensional(2D) cell culture

in vitro three-dimensional(3D) cell culture is much closer to the growth microenvironment of cells. The smart hydrogel has good biocompatibility. The special structure and property of smart hydrogel can mimic the extracellular matrix(ECM) and help us achieve the goal of 3D cells culture. Furthermore

the smart hydrogel also has sensitive response to the external environment stimulus

which can change the cells’ microenvironment and enable us to study cell behaviors in 3D model. In this review

we discuss the smart hydrogel and 3D cell culture

review the different types of smart responsive hydrogel and introduce the influence of 3D scaffold on cell behaviors.

关键词

智能水凝胶三维细胞培养温度响应pH响应光响应

Keywords

Smart hydrogelThree-dimensional cell cultureThermo-responsivepH-ResponsivePhoto-responsive

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