Research Progress of Thermo-responsive Amino Acid-Polymer Hybrid Materials

Chun-hui LUO

doi:10.14028/j.cnki.1003-3726.2016.01.004

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Research Progress of Thermo-responsive Amino Acid-Polymer Hybrid Materials

更新时间：2022-09-12

- Research Progress of Thermo-responsive Amino Acid-Polymer Hybrid Materials
- Polymer Bulletin Vol. 29, Issue 1, Pages: 25-30(2016)
- 作者机构：
  
  北方民族大学化学与化学工程学院，国家民委化工技术重点实验室，银川 750021
- 作者简介：
- 基金信息：
- DOI：10.14028/j.cnki.1003-3726.2016.01.004
  CLC：
- Published：20 January 2016，
  
  Received：14 January 2015，
  
  Revised：11 May 2015，
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Chun-hui LUO. Research Progress of Thermo-responsive Amino Acid-Polymer Hybrid Materials. [J]. Polymer Bulletin 29(1):25-30(2016)
DOI：

Chun-hui LUO. Research Progress of Thermo-responsive Amino Acid-Polymer Hybrid Materials. [J]. Polymer Bulletin 29(1):25-30(2016) DOI： 10.14028/j.cnki.1003-3726.2016.01.004.

摘要

温敏性聚合物在组织工程、药物传递和缓释、生物传感器以及纳米药物中有着广泛的应用。聚N-异丙基丙烯酰胺

聚甲基丙烯酸寡聚乙二醇酯以及吡咯烷酮基聚合物是典型的温敏性聚合物。然而

这些温敏性聚合物功能相对单一。现代科技的发展

对温敏性材料提出了新的要求

如具有多重刺激响应特性、生物相容性好、可生物降解以及其他功能。氨基酸是两性分子

具有手性、生物相容性好、多官能团、二级结构丰富等优点。以氨基酸或多肽构筑温敏聚合物可以将聚合物的多样性与氨基酸的优点结合起来

本文介绍了此类材料的合成及研究进展。

Abstract

Thermo-responsive polymers are wildly used in sensors

nanotechnology

gene engineering

and other fields. Poly(N-isopropylacryl amide)

poly[oligo(ethylene glycol) (meth)acrylates] and pyrrolidone based polymers are typical thermo-sensitive polymers. However

traditional thermo-responsive polymers displayed relatively monotonous function. With the development of technology

thermo-responsive polymers were expected to display multi-stimuli sensitive mechanism

biocompatibility

bio-degradation and other functions. Amino acids/polypeptides have the characteristic of chirality

biocompatibility

multifunctional group and diverse secondary structures. Using amino acids/peptides to synthesize thermo-responsive polymers can incorporate the advantages of bio-molecule and the superiorities of synthetic polymers together. The research progress of this hybrid material is reviewed.

关键词

氨基酸衍生物多肽温度响应杂化材料

Keywords

Amino acid derivatePolypeptideThermo-responsiveHybrid materials

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