Research Progresses of Poly-ε-caprolactone as Drug Carriers

Xiang-jun GE; Yuan TIAN; Xiang-yuan XIONG; Yan-chun GONG; Zi-ling LI; Yu-ping LI

doi:10.14028/j.cnki.1003-3726.2017.03.002

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Research Progresses of Poly-ε-caprolactone as Drug Carriers

更新时间：2022-09-06

- Research Progresses of Poly-ε-caprolactone as Drug Carriers
- Polymer Bulletin Vol. 30, Issue 3, Pages: 11-18(2017)
- 作者机构：
  
  1.江西科技师范大学生命科学学院，南昌 330013
  2.中国医药工业有限公司，北京 100190
- 作者简介：
- 基金信息：
- DOI：10.14028/j.cnki.1003-3726.2017.03.002
  CLC：
- Published：01 March 2017，
  
  Received：31 August 2016，
  
  Revised：09 November 2016，
扫描看全文
Xiang-jun GE, Yuan TIAN, Xiang-yuan XIONG, Yan-chun GONG, Zi-ling LI, Yu-ping LI. Research Progresses of Poly-ε-caprolactone as Drug Carriers. [J]. Polymer Bulletin 30(3):11-18(2017)
DOI：

Xiang-jun GE, Yuan TIAN, Xiang-yuan XIONG, Yan-chun GONG, Zi-ling LI, Yu-ping LI. Research Progresses of Poly-ε-caprolactone as Drug Carriers. [J]. Polymer Bulletin 30(3):11-18(2017) DOI： 10.14028/j.cnki.1003-3726.2017.03.002.

摘要

聚己内酯（poly-ε-caprolactone，PCL）是一种人工合成的聚酯类高分子材料，对人体无毒，具有良好的生物相容性、生物可降解性和无免疫原性。PCL还对其它聚合物具有良好的相容性，可以制备出多种性能优良的共聚物或共混物，因此PCL及其共聚物、共混物作为药物载体的研究受到国内外研究者的高度重视。此外，PCL因其在人体中的降解过程十分缓慢可作为药物控释材料，目前已经获得美国FDA的批准。本文将从聚己内酯的合成与改性及其各剂型在药物载体方面的研究进展进行综述。

Abstract

Poly-ε-caprolactone(PCL) is a synthetic polyester with excellent biocompatibility

biodegradability

non-immunogenicity and non-toxic to human body. Due to its good compatibility with other polymers

it can be prepared into a variety of copolymers or blends with excellent properties. Therefore

research about PCL and its copolymers and blends as drug carriers have stolen the spotlight of synthetic macromolecular drug delivery systems. In addition

due to its long-term degradation in vivo

PCL used as materials for controlled release of drugs has already received US FDA’s approval. In this article

progresses in PCL synthesis and modification and its formulations of drug delivery system are reviewed.

关键词

聚己内酯共聚物水溶胶纳米粒子胶束囊泡

Keywords

Poly-ε-caprolactoneco-PolymerHydrogelNanoparticlesMicelleVesicle

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