As a kind of nonsteroidal anti-inflammatory drug

ibuprofen is widely applied in clinic due to its good antipyretic

analgesic and anti-inflammatory effects. However

there are still some adverse effects in its practical applications. This promotes scientists to improve the performance of ibuprofen by chemical modification ( e. g. esterification

amidation) or polymeric loading. Their research progress is summarized. It is pointed that the bio-based polymer conjugates have good prospect in the future due to the combination of chemical modification and slow release function into one improvement method.