Research on Synthesis and Drug Release of Rutin Alginate/Chitosan Microspheres Prepared by Layer-by-layer Self-assembly Method

Jie-hui CAI; Ying-quan YANG; Sheng-tao XIE; Yan-fei ZHENG

doi:10.14028/j.cnki.1003-3726.2018.05.008

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Research on Synthesis and Drug Release of Rutin Alginate/Chitosan Microspheres Prepared by Layer-by-layer Self-assembly Method

更新时间：2022-09-05

- Research on Synthesis and Drug Release of Rutin Alginate/Chitosan Microspheres Prepared by Layer-by-layer Self-assembly Method
- Polymer Bulletin Vol. 31, Issue 5, Pages: 58-66(2018)
- 作者机构：
  
  1.广西民族师范学院化学化工学院, 崇左 532200
  2.中信大锰矿业责任有限公司崇左分公司, 崇左 532200
- 作者简介：
- 基金信息：
- DOI：10.14028/j.cnki.1003-3726.2018.05.008
  CLC：
- Published：20 May 2018，
  
  Received：19 October 2017，
  
  Revised：07 March 2018，
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Jie-hui CAI, Ying-quan YANG, Sheng-tao XIE, Yan-fei ZHENG. Research on Synthesis and Drug Release of Rutin Alginate/Chitosan Microspheres Prepared by Layer-by-layer Self-assembly Method. [J]. Polymer Bulletin 31(5):58-66(2018)
DOI：

Jie-hui CAI, Ying-quan YANG, Sheng-tao XIE, Yan-fei ZHENG. Research on Synthesis and Drug Release of Rutin Alginate/Chitosan Microspheres Prepared by Layer-by-layer Self-assembly Method. [J]. Polymer Bulletin 31(5):58-66(2018) DOI： 10.14028/j.cnki.1003-3726.2018.05.008.

摘要

为了提高载药微球的成球性和机械性能，以搅拌共沉淀法制得的CaCO

微球为吸附剂，采用离子交联法制备载芸香叶苷的海藻酸钙（ALG-Ca）模板凝胶，利用层层自组装技术（LBL）将带有相反电荷的海藻酸钠（ALG）和壳聚糖盐酸盐（CHI）逐层络合得到不同膜层的载芸香叶苷微球。通过FT-IR、SEM、溶胀实验和体外释药实验对载药微球的性能进行研究，结果表明，以CaCO

微球为吸附剂可提高载药ALG-Ca/（CHI/ALG）

微球的机械性能和成球性，微球剖面边缘出现层层膜结构且膜层总厚度约为20.22

m，载芸香叶苷ALG-Ca/（CHI/ALG）

微球释药实验发现，在37℃、pH=1.2生理盐水和pH=6.8 PBS溶液的环境下，聚合物膜层数越多对芸香叶苷缓释能力越强。

Abstract

In order to improve the spheronization and mechanical properties of drug-loaded microspheres

rutin-loaded microspheres were prepared

where CHI with oppositely charged ALG-Na was deposited on different layers through complexation by layer-by-layer self-assembly method. In this method

CaCO

microspheres as adsorbent were made by stirring coprecipitation method and rutin-loaded ALG-Ca template gel was prepared by ion cross-linking method. This paper utilized FT-IR、SEM、swelling test and drug release experiment in vitro to characterize the properties of drug-loaded microspheres. The results showed that CaCO

microspheres as adsorbent could enhance the spheronization and mechanical properties of the drug-loaded ALG-Ca/(CHI/ALG)

microspheres. The multilayer structure were formed on edge of vertical section of microsphere. The membrane thickness was approximately 20.22

m. Meanwhile

by investigating the drug release experiments of ALG-Ca/(CHI/ALG)

microspheres

it was found that when pH of the normal saline was 1.2

pH of PBS was 6.8 and the temperature of the solution was 37℃

the more layers the microspheres have

the lower the rutin release rate is.

关键词

CaCO3微球层层自组装海藻酸钠壳聚糖盐酸盐芸香叶苷

Keywords

CaCO3 microsphereLayer-by-layer self-assemblyAlginateChitosan hydrochlorideRutin

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