The chemically modified hyaluronic acid not only retains good biocompatibility and biodegradability

but also obtains unique properties

such as anti-degradation

viscoelasticity and so on. Using this property

cross-linked hyaluronic acid can be used for vascular embolization. In this study

The microspheres was prepared by emulsion cross-linking technique. The effect of the initial reaction concentration

emulsifying shearing speed and the ratio of oil and water on pellet formation and size distribution was investigated

light microscope were used to observe the microspheres

the physical and chemical properties of the microscope were studied. The results show that the surface of the microspheres is smooth

the shape of the spheres is complete

and the microspheres have good compressive deformation resistance. It meets the requirements of microsphere embolization and provides the theoretical basis for the experimental study in vivo.