Hyaluronic Acid-based Carriers for Antitumor Drug Delivery

Chao-ping FU; Li-ming ZHANG

doi:10.14028/j.cnki.1003-3726.2019.02.012

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Hyaluronic Acid-based Carriers for Antitumor Drug Delivery

The 30th Anniversary Issue II | 更新时间：2022-09-02

- Hyaluronic Acid-based Carriers for Antitumor Drug Delivery
- Polymer Bulletin Vol. 32, Issue 2, Pages: 103-111(2019)
- 作者机构：
  
  中山大学材料科学与工程学院，广州 510275
- 作者简介：
- 基金信息：
- DOI：10.14028/j.cnki.1003-3726.2019.02.012
  CLC：
- Published：20 February 2019，
  
  Received：11 November 2018，
  
  Revised：18 November 2018，
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Chao-ping FU, Li-ming ZHANG. Hyaluronic Acid-based Carriers for Antitumor Drug Delivery. [J]. Polymer Bulletin 32(2):103-111(2019)
DOI：

Chao-ping FU, Li-ming ZHANG. Hyaluronic Acid-based Carriers for Antitumor Drug Delivery. [J]. Polymer Bulletin 32(2):103-111(2019) DOI： 10.14028/j.cnki.1003-3726.2019.02.012.

摘要

透明质酸是细胞外基质的主要成分之一，具有良好的生物相容性、可生物降解性、非免疫原性，分子结构中还富含可供进一步化学修饰改性的羧基、羟基等反应性功能基团，近年来已成为设计和制备抗肿瘤药物递送载体的原村料。此外，透明质酸的CD44受体在许多肿瘤细胞表面均为高表达状态，以透明质酸为原材料制备的抗肿瘤药物载体对CD44高表达的肿瘤细胞具有主动靶向性。本文对基于透明质酸设计的前体药物（前药）、有机载体材料（胶束、脂质体、纳米颗粒、微泡、水凝胶等）和无机复合载体材料（纳米金、量子点、碳纳米管、二氧化硅）等抗肿瘤药物载体进行了综述。

Abstract

Hyaluronic acid (HA) is the main component of the extracellular matrix (ECM) and is widely used in anticancer drug delivery. It is biocompatible

biodegradable

non-toxic

non-immunogenic and rich of carboxyl

hydroxyl function groups. Moreover

cancer cells have increased number of HA receptors in contrast to normal cells. Thus

the antitumor drug delivery system prepared with hyaluronic acid has active targeting for the high CD44-expressing tumor cells. In this paper

the research progress of antitumor drug carriers based on hyaluronic acid was summarized in the field of prodrugs

organic carrier materials (micelles

liposomes

nanoparticles

microbubbles

hydrogels

etc.)

and inorganic composite carrier materials (nano gold

quantum dots

carbon nanotubes

silicon dioxide

etc.).

关键词

透明质酸抗肿瘤药物载体前药药物递送

Keywords

Hyaluronic acidAntitumor drug carriersProdrugsDrug delivery

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