In vitro

interaction of methylmercury and inorganic mercury with immunoglobulin IgG was studied using the small angle X-ray scattering (SAXS) method to detect whether the structure of IgG has changed. After processing by S.exe software package

Kratky plot

distance distribution function and protein shape data of the reaction molecule conformation were obtained. Combining the various parameters

it was found that different reaction times and different mercury forms can cause the folding and unfolding of the molecular structure of IgG. these results indicate that mercury can affect the structure of immunoglobulins.