Preparation and Properties of Electrospun Polyvinyl Alcohol/Chondroitin Sulfate Fiber Scaffold

Wan-ying WANG; Xiao-su QIN; Ting-ting YAN; Xi-liang CHEN; Qing-hua CHEN

doi:10.14028/j.cnki.1003-3726.2019.09.008

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Preparation and Properties of Electrospun Polyvinyl Alcohol/Chondroitin Sulfate Fiber Scaffold

更新时间：2022-09-02

- Preparation and Properties of Electrospun Polyvinyl Alcohol/Chondroitin Sulfate Fiber Scaffold
- Polymer Bulletin Vol. 32, Issue 9, Pages: 74-81(2019)
- 作者机构：
  
  昆明理工大学材料科学与工程学院，昆明 650500
- 作者简介：
- 基金信息：
- DOI：10.14028/j.cnki.1003-3726.2019.09.008
  CLC：
- Published：20 September 2019，
  
  Received：19 September 2018，
  
  Revised：11 April 2019，
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Wan-ying WANG, Xiao-su QIN, Ting-ting YAN, Xi-liang CHEN, Qing-hua CHEN. Preparation and Properties of Electrospun Polyvinyl Alcohol/Chondroitin Sulfate Fiber Scaffold. [J]. Polymer Bulletin 32(9):74-81(2019)
DOI：

Wan-ying WANG, Xiao-su QIN, Ting-ting YAN, Xi-liang CHEN, Qing-hua CHEN. Preparation and Properties of Electrospun Polyvinyl Alcohol/Chondroitin Sulfate Fiber Scaffold. [J]. Polymer Bulletin 32(9):74-81(2019) DOI： 10.14028/j.cnki.1003-3726.2019.09.008.

摘要

以聚乙烯醇和硫酸软骨素为原料，采用静电纺丝设备制备聚乙烯醇／硫酸软骨素纤维支架，并通过正交实验法探究得出该支架材料的最佳制备方案。采用SEM、FT-IR等方法分析纤维支架的形貌、成分以及结构特征，并对该材料进行细胞毒性分析和降解性能测试。结果表明，当8%聚乙烯醇与5%硫酸软骨素溶液体积比为3:1，纺丝电压为16 kV，推注速度为0.2mm/min时，纺丝效果最好；该材料的细胞毒性为0或1，即无细胞毒性，在降解60天时的降解率约为75%，因此该材料在软骨修复方面有良好的应用前景。

Abstract

Polyvinyl alcohol/Chondroitin sulfate fiber scaffolds were prepared by electrospinning with polyvinyl alcohol and chondroitin sulfate as raw materials

and the optimum preparation scheme of composite porous scaffolds was obtained by orthogonal experiment. The morphology and structure of the fiber scaffolds were characterized by SEM and FTIR

and tested the cytotoxicity and degradation proformance of the material. The results shows that when the volume ratio of polyvinyl alcohol to CS solution is 3 : 1

the spinning voltage is 16 kV

and the injection rate is 0.2mm/min

the spinning effect is the best. The cytotoxicity of the material is 0 or 1

that's to say

the material is no cytotoxicity

the degradation rate is about 75% at 60 days of degradation

so the fiber scaffolds has a good application prospect in cartilage repair.

关键词

软骨支架静电纺丝聚乙烯醇硫酸软骨素

Keywords

Cartilage scaffoldsElectrospinningPolyvinyl alcoholChondroitin sulfate

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