Advances in the Evaluation of Blood Compatibility of Blood-contact Biomaterials

Zheng QIN; Qin-bo YANG; Bai-hai SU

doi:10.14028/j.cnki.1003-3726.2021.02.001

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Advances in the Evaluation of Blood Compatibility of Blood-contact Biomaterials

更新时间：2022-08-30

- Advances in the Evaluation of Blood Compatibility of Blood-contact Biomaterials
- Polymer Bulletin Vol. 34, Issue 2, Pages: 1-8(2021)
- 作者机构：
  
  四川大学华西医院肾脏内科,成都 610041
- 作者简介：
- 基金信息：
- DOI：10.14028/j.cnki.1003-3726.2021.02.001
  CLC：
- Published：20 February 2021，
  
  Received：30 June 2019，
  
  Revised：04 December 2020，
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Zheng QIN, Qin-bo YANG, Bai-hai SU. Advances in the Evaluation of Blood Compatibility of Blood-contact Biomaterials. [J]. Polymer Bulletin 34(2):1-8(2021)
DOI：

Zheng QIN, Qin-bo YANG, Bai-hai SU. Advances in the Evaluation of Blood Compatibility of Blood-contact Biomaterials. [J]. Polymer Bulletin 34(2):1-8(2021) DOI： 10.14028/j.cnki.1003-3726.2021.02.001.

摘要

生物材料的血液相容性是决定该材料能否在临床成功应用的重要标准之一。当材料与血液接触后

会引起溶血、凝血和免疫等一系列反应

机制复杂且受多种因素影响。因此

在材料临床应用前需根据ISO10993-4进行生物相容性评价

血液相容性评价是其中重要部分

但目前尚未形成统一的评价标准与评价体系。本文总结了近年对血液相容性评价的主要方法

为今后生物材料血液相容性评价体系的建立提供参考。

Abstract

The blood compatibility of biomaterials is one of the important criteria for the successful clinical application. When materials come into contact with blood

they will cause a series of complex reactions

such as hemolysis

coagulation and immunity

and the mechanism is complex and affected by a variety of factors. Therefore

biocompatibility evaluation of materials should be conducted according to ISO 10993-4 before their clinical application. Blood compatibility evaluation is an important part of it

but there is no unified evaluation standard and index so far. In this paper

the main methods of blood compatibility evaluation in recent years were summarized to provide reference for the establishment of biomaterial blood compatibility evaluation system in the future.

关键词

生物材料血液相容性评价

Keywords

BiomaterialsBlood compatibilityEvaluation

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