Progress of Chitosan Study in Hemostatic Sponge

Xue BAI; Hua BI; Xue-feng ZHANG; Rui-yan MEI; Xiao-xia FAN

doi:10.14028/j.cnki.1003-3726.2021.03.003

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Progress of Chitosan Study in Hemostatic Sponge

更新时间：2022-08-30

- Progress of Chitosan Study in Hemostatic Sponge
- Polymer Bulletin Vol. 34, Issue 3, Pages: 13-19(2021)
- 作者机构：
  
  延安大学医学院,延安 716000
- 作者简介：
- 基金信息：
- DOI：10.14028/j.cnki.1003-3726.2021.03.003
  CLC：
- Published：20 March 2021，
  
  Received：01 September 2019，
  
  Revised：04 January 2021，
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Xue BAI, Hua BI, Xue-feng ZHANG, Rui-yan MEI, Xiao-xia FAN. Progress of Chitosan Study in Hemostatic Sponge. [J]. Polymer Bulletin 34(3):13-19(2021)
DOI：

Xue BAI, Hua BI, Xue-feng ZHANG, Rui-yan MEI, Xiao-xia FAN. Progress of Chitosan Study in Hemostatic Sponge. [J]. Polymer Bulletin 34(3):13-19(2021) DOI： 10.14028/j.cnki.1003-3726.2021.03.003.

摘要

壳聚糖具有抗菌、止血、无毒、促凝血、可降解以及良好的生物相容性等特点

现已被广泛应用于止血海绵的制备研究。本文针对单纯壳聚糖力学强度不足的缺点

综述了壳聚糖添加交联剂京尼平、醛类、单宁酸增强力学强度的研究进展;针对单纯壳聚糖不易溶于水的特点

综述了壳聚糖改性为羧甲基壳聚糖

壳聚糖季铵盐和烷基化壳聚糖增加或减少溶解度的研究进展;针对单纯壳聚糖止血效果不佳的特点

综述了通过加入聚乙烯醇、明胶、胶原等有机或无机材料改善其止血效果的研究进展。

Abstract

As a new hemostatic material

chitosan has been widely studied in recent years based on the characteristics of antibiosis

hemostasis

non-toxic

thromboplastin

biodegradation and biocompatibility. According to the defect of mechanical properties

hydrophobicity and slow hemostasis rate of chitosan

this paper review the research progress of chitosan with different cross-linking agents for increasing the mechanical properties

such as Jingniping

aldehydes and tannic acids. Furthermore

we also report the research progress of modification of chitosan for enhancing or decreasing solubility in water

such as carboxymethyl chitosan

chitosan quaternary ammonium salt and alkylated chitosan. Finally

we review chitosan composites by adding organic and inorganic materials for improving the hemostatic potential

including polyvinyl alcohol

gelatin and collagen.

关键词

壳聚糖止血海绵交联剂止血

Keywords

ChitosanHemostatic spongeCross-linking agentsHemostasis

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