Functional Modification of Chitosan and its Application in Controlled Release Nano-drug Carrier

Qing-yan PAN; Chuang ZHOU; Zi-ming YANG; Zu-yu HE; Chao WANG; Yun-hao LIU; Shu-hui SONG; Hui GU; Pu-wang LI

doi:10.14028/j.cnki.1003-3726.2021.05.008

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Functional Modification of Chitosan and its Application in Controlled Release Nano-drug Carrier

更新时间：2022-08-30

- Functional Modification of Chitosan and its Application in Controlled Release Nano-drug Carrier
- Polymer Bulletin Vol. 34, Issue 5, Pages: 80-87(2021)
- 作者机构：
  
  1.中国热带农业科学院南亚热带作物研究所,广东湛江 524091
  2.华中农业大学食品科学技术学院,湖北武汉 430070
- 作者简介：
- 基金信息：
- DOI：10.14028/j.cnki.1003-3726.2021.05.008
  CLC：
- Published：20 May 2021，
  
  Received：2020，
  
  Revised：2020，
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Qing-yan PAN, Chuang ZHOU, Zi-ming YANG, Zu-yu HE, Chao WANG, Yun-hao LIU, Shu-hui SONG, Hui GU, Pu-wang LI. Functional Modification of Chitosan and its Application in Controlled Release Nano-drug Carrier. [J]. Polymer Bulletin 34(5):80-87(2021)
DOI：

Qing-yan PAN, Chuang ZHOU, Zi-ming YANG, Zu-yu HE, Chao WANG, Yun-hao LIU, Shu-hui SONG, Hui GU, Pu-wang LI. Functional Modification of Chitosan and its Application in Controlled Release Nano-drug Carrier. [J]. Polymer Bulletin 34(5):80-87(2021) DOI： 10.14028/j.cnki.1003-3726.2021.05.008.

摘要

壳聚糖为天然多糖甲壳素脱除部分乙酰基的产物

因其优异的理化性质和生物学活性

成为生物医学应用中最有前景的聚合物之一。由于壳聚糖在中性和碱性溶液中溶解性较差

其应用受到了一定限制

通常对其进行功能化改性

生成一系列壳聚糖衍生物。壳聚糖衍生物可改善壳聚糖的水溶性、生物活力及力学性能

从而提高其利用价值

扩大其应用领域。本文综述了几种壳聚糖常用的功能化改性方法

包括接枝共聚、交联、羧甲基化、酰基化、烷基化。并介绍了改性壳聚糖作为药物载体应用的研究进展

旨在为改性壳聚糖的研究提供一定理论基础。

Abstract

Chitosan as natural polysaccharide chitin removal of acetyl products

because of their excellent physical and chemical properties and biological activities

become one of the most promising polymer in biomedical applications

as a result of chitosan in poor solubility in neutral and alkaline solution

its application is limited by a certain

Usually

chitosan is functionalized and modified to generate a series of chitosan derivatives. Chitosan derivatives can improve the water solubility

biological activity and mechanical properties of chitosan

so as to enhance its utilization value and expand its application field. Several functionalization methods of chitosan

including graft copolymerization

crosslinking

carboxymethylation

acylation and alkylation

were reviewed in this paper. The research progress of the application of modified chitosan as drug carrier was introduced in order to provide some theoretical basis for the study of modified chitosan.

关键词

壳聚糖功能化改性药物载体

Keywords

ChitosanFunctional modificationDrug carrier

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Related Institution

Fujian Key Laboratory of Novel Functional Textile Fibers and Materials, Minjiang University

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