Preparation and Physicochemical Properties of PCL/HA Bone Tissue Engineering Porous Scaffold

Ke-xin LI; Ju-jing ZHONG; Hua-chao GUO; Pan LI; Zhi-min JIANG; Ting-ting YAN

doi:10.14028/j.cnki.1003-3726.2021.05.009

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Preparation and Physicochemical Properties of PCL/HA Bone Tissue Engineering Porous Scaffold

更新时间：2022-08-30

- Preparation and Physicochemical Properties of PCL/HA Bone Tissue Engineering Porous Scaffold
- Polymer Bulletin Vol. 34, Issue 5, Pages: 88-95(2021)
- 作者机构：
  
  昆明理工大学材料科学与工程学院,昆明 650000
- 作者简介：
- 基金信息：
- DOI：10.14028/j.cnki.1003-3726.2021.05.009
  CLC：
- Published：20 May 2021，
  
  Received：16 March 收稿:2020，
  
  Revised：修回:2020-12，
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Ke-xin LI, Ju-jing ZHONG, Hua-chao GUO, Pan LI, Zhi-min JIANG, Ting-ting YAN. Preparation and Physicochemical Properties of PCL/HA Bone Tissue Engineering Porous Scaffold. [J]. Polymer Bulletin 34(5):88-95(2021)
DOI：

Ke-xin LI, Ju-jing ZHONG, Hua-chao GUO, Pan LI, Zhi-min JIANG, Ting-ting YAN. Preparation and Physicochemical Properties of PCL/HA Bone Tissue Engineering Porous Scaffold. [J]. Polymer Bulletin 34(5):88-95(2021) DOI： 10.14028/j.cnki.1003-3726.2021.05.009.

摘要

以聚己内酯和羟基磷灰石粉体为原料

通过溶剂浇铸/真空挥发/粒子沥滤法(SC/VV/PL)成功制备出复合多孔PCL/HA支架

并通过X射线衍射仪(XRD)、扫描电镜(SEM)、红外分析仪(FT-IR)等对制备所得的支架物相成分、微观形貌等进行表征

研究了支架的相关理化性能

成功制备出具有较高孔隙率且力学性能良好的PCL/HA复合多孔支架

孔径大小在100~300μm 之间

孔隙率达到83%~89%

满足骨组织工程支架对多孔结构的要求;研究同时表明

HA 的复合可提高了支架的结晶度及其力学强度

抗压强度达到3.6~5.1MPa。

Abstract

Polycaprolactone and hydroxyapatite powders were used as raw materials to prepare polymer threedimensional porous scaffolds by solvent casting/vacuum evaporation/particle leaching (SC/VV/PL). X-ray diffraction (XRD)

scanning electron microscopy (SEM) and infrared analyzer (FT-IR) characterized the composition and microstructure of the scaffold. The related physical and chemical properties of the scaffold were studied. The results show that PCL/HA composite scaffolds with high porosity and good mechanical properties are successfully prepared. The pore size of PCL/HA composite scaffolds is between 100~300μm

the porosity has reached to 83%~89%

which is in line with the requirements of porous scaffolds. The requirements also show that the composite of HA can improve the crystallinity and mechanical strength of the scaffold

and the compressive strength reaches 3.6~5.1MPa.

关键词

聚己内酯羟基磷灰石多孔陶瓷材料力学性能

Keywords

PolycaprolactoneHydroxyapatitePorous ceramic materialMechanical strength

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