The Researh of Hydrogel Controllably Release Hydrophobic Drugs under Ultrasound

You-peng WANG; Wei LI; Xing-li SHI; Wei-hua LV; Xin-jie ZHANG

doi:10.14028/j.cnki.1003-3726.2021.11.009

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The Researh of Hydrogel Controllably Release Hydrophobic Drugs under Ultrasound

更新时间：2022-08-30

- The Researh of Hydrogel Controllably Release Hydrophobic Drugs under Ultrasound
- Polymer Bulletin Vol. 34, Issue 11, Pages: 64-70(2021)
- 作者机构：
  
  兰州石化职业技术学院石油化学工程学院,兰州 730060
- 作者简介：
- 基金信息：
- DOI：10.14028/j.cnki.1003-3726.2021.11.009
  CLC：
- Published：20 November 2021，
  
  Received：26 September 2020，
  
  Revised：24 April 2021，
扫描看全文
You-peng WANG, Wei LI, Xing-li SHI, Wei-hua LV, Xin-jie ZHANG. The Researh of Hydrogel Controllably Release Hydrophobic Drugs under Ultrasound. [J]. Polymer Bulletin 34(11):64-70(2021)
DOI：

You-peng WANG, Wei LI, Xing-li SHI, Wei-hua LV, Xin-jie ZHANG. The Researh of Hydrogel Controllably Release Hydrophobic Drugs under Ultrasound. [J]. Polymer Bulletin 34(11):64-70(2021) DOI： 10.14028/j.cnki.1003-3726.2021.11.009.

摘要

PVA水溶液与溶解疏水药物的硅油混合后经冷冻解冻处理可制得一种高韧性物理水凝胶。荧光显微镜发现这种水凝胶具有良好的结构稳定性

硅油在水凝胶中以小液滴形式分散

五周以后观察不到液滴聚集或明显的相分离。水凝胶的机械性能随着硅油含量增加而增大

表明硅油不仅作为药物储存器来封装疏水性药物

还与PVA链疏水界面产生强吸附性能。本研究系统考察了复合水凝胶超声控制下的疏水药物的释放行为

超声刺激能明显加快水凝胶的药物释放速率。超声引发药物释放机理表明

超声机械效应是诱导疏水药物释放的主要原因。

Abstract

Use freezing/thawing treatment prepared a high toughness composite hydrogel from hydrophobic drug-loaded silicone oil dispersed in poly(vinyl alcohol) solution. The hydrogel owned a relatively stable structure through fluorescent microscopy

silicone oil was dispersed and permeated in the hydrogel matrix as microdroplets

no aggregation or migration were observed when the hydrogel sample was placed stationary after 5 weeks. The mechanical properties of hydrogel enhanced proportionally with increasing the silicone oil content

indicating silicone oil not only act as drug reservoirs dispersed within the hydrogel matrix

but also improved the mechanical properties for strong adsorption effect of PVA chains on hydrophobic surfaces.Ultrasound is used to control trigger the hydrophobic drug release from the hydrogel

the result showed the drug were instantly and rapidly released under ultrasound exposure. Mechanism of ultrasound controlled drug release is studied in this paper

and the results indicate the mechanical effect is the main reason.

关键词

超声水凝胶控制释放疏水药物聚乙烯醇

Keywords

UltrasoundHydrogelControlled releaseHydrophobic drugPVA

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