Research Progress of Acid-Responsive Amphiphilic Polymers as Drug Carriers

Jing-yi LIU; Yu ZHOU; Jia-yu PENG; Wang-wang TAO; Hong-xiang CHEN

doi:10.14028/j.cnki.1003-3726.2021.12.003

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Research Progress of Acid-Responsive Amphiphilic Polymers as Drug Carriers

更新时间：2022-08-30

- Research Progress of Acid-Responsive Amphiphilic Polymers as Drug Carriers
- Polymer Bulletin Vol. 34, Issue 12, Pages: 22-30(2021)
- 作者机构：
  
  武汉科技大学,煤转化与新型碳材料湖北省重点实验室,武汉 430081
- 作者简介：
- 基金信息：
- DOI：10.14028/j.cnki.1003-3726.2021.12.003
  CLC：
- Published：20 December 2021，
  
  Received：19 September 2020，
  
  Revised：27 April 2021，
扫描看全文
Jing-yi LIU, Yu ZHOU, Jia-yu PENG, Wang-wang TAO, Hong-xiang CHEN. Research Progress of Acid-Responsive Amphiphilic Polymers as Drug Carriers. [J]. Polymer Bulletin 34(12):22-30(2021)
DOI：

Jing-yi LIU, Yu ZHOU, Jia-yu PENG, Wang-wang TAO, Hong-xiang CHEN. Research Progress of Acid-Responsive Amphiphilic Polymers as Drug Carriers. [J]. Polymer Bulletin 34(12):22-30(2021) DOI： 10.14028/j.cnki.1003-3726.2021.12.003.

摘要

目前临床上常用的抗癌药物大多为小分子

其存在水溶性差、释药速率不可控、毒副作用大等问题。鉴于两亲性聚合物可自组装形成“核壳”结构的纳米胶束以及正常组织呈中性、而肿瘤组织和细胞内显微酸性的特点

近十几年来具有酸响应性能的两亲性聚合物抗癌药物载体得到了广泛关注和研究。本文着重介绍了酸响应两亲性聚合物药物载体的结构特点

并从提高载体在血液循环中的稳定性、增强细胞摄取能力和控制药物释放等三个方面阐述了酸响应两亲性聚合物药物载体的功能特性

同时展望了其研究前景。

Abstract

At present

antitumor drugs in clinic are mostly small molecules

which have some disadvantages such as poor water solubility

uncontrolled drug release behavior and high toxicity. Due to amphiphilic polymers can self-assemble to form nano-micelles with "core-shell" structure and tumor tissues and their intracellular environment are weakly acidic as compared to the neutral normal tissues

the acid-responsive amphiphilic polymers as antitumor drug carriers have drawn a lot of attentions in the recent decade. This article emphatically introduced the structure characteristics of acid-responsive amphiphilic polymers as drug carriers

and the functional characteristics were expounded from improving the stability of micelle in blood circulation

enhancing cell uptake ability and controlling drug release. In addition

the future research prospect of acid-responsive amphiphilic polymers as drug carriers was also put forward.

关键词

酸响应两亲性聚合物药物载体

Keywords

Acid-responsiveAmphiphilicPolymerDrug carrier

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