Preparation and Drug Release Behavior of Nano-drug Carrier Based on Poly(glutamate-tyrosine-alanine) Block Copolymer

Xiao-xu XU; Qi-fan CHEN; Yan-hua LU; Pan-pan GU

doi:10.14028/j.cnki.1003-3726.2021.12.007

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Preparation and Drug Release Behavior of Nano-drug Carrier Based on Poly(glutamate-tyrosine-alanine) Block Copolymer

更新时间：2022-08-30

- Preparation and Drug Release Behavior of Nano-drug Carrier Based on Poly(glutamate-tyrosine-alanine) Block Copolymer
- Polymer Bulletin Vol. 34, Issue 12, Pages: 56-62(2021)
- 作者机构：
  
  辽东学院化工与机械学院,丹东 118003
- 作者简介：
- 基金信息：
- DOI：10.14028/j.cnki.1003-3726.2021.12.007
  CLC：
- Published：20 December 2021，
  
  Received：07 August 2021，
  
  Revised：27 August 2021，
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Xiao-xu XU, Qi-fan CHEN, Yan-hua LU, Pan-pan GU. Preparation and Drug Release Behavior of Nano-drug Carrier Based on Poly(glutamate-tyrosine-alanine) Block Copolymer. [J]. Polymer Bulletin 34(12):56-62(2021)
DOI：

Xiao-xu XU, Qi-fan CHEN, Yan-hua LU, Pan-pan GU. Preparation and Drug Release Behavior of Nano-drug Carrier Based on Poly(glutamate-tyrosine-alanine) Block Copolymer. [J]. Polymer Bulletin 34(12):56-62(2021) DOI： 10.14028/j.cnki.1003-3726.2021.12.007.

摘要

双亲性聚合物以其独特的物理结构和化学性质在生物医学

尤其在药物缓释领域具有重要的应用前景。本文首先设计并合成了具有亲疏水性的聚(天冬氨酸-酪氨酸-丙氨酸)嵌段聚合物

其结构通过红外光谱(FT-IR)与核磁共振氢谱(

H NMR)的表征;其次

基于该嵌段聚合物通过自组装的方式对模型药物阿霉素进行了包载

构建了具有pH 响应的药物纳米载体

采用扫描电子显微镜(SEM)与采用激光粒度仪(DLS)表征了载药纳米粒子的形貌、粒径大小及分布。研究表明

载药纳米粒子在溶液中呈现球形

其粒径小于220nm

且具有明显的pH 响应性

在酸性条件下的释放效果明显高于中性和碱性条件。此外

体外细胞毒性实验表明

该聚氨基酸材料对L-929细胞无毒性。

Abstract

Due to the unique physical structure and chemical properties

amphiphilic polymers have an important role in biomedicine

especially in the field of drug release. In this study

a new block copolymer poly (aspartate-tyrosine-alanine) was synthesized by ring-opening polymerization

and its structure was characterized by FT-IR and 1H-NMR. The model drug doxorubicin was loaded by self-assembly based on the block polymer

and the drug nanocarriers with pH response were constructed. The morphology

particle size and distribution of drug-loaded nanoparticles were characterized by scanning electron microscopy (SEM) and dynamic light scattering (DLS)

respectively. The results showed that the particle size of drug-loaded nanoparticles in solution is less than 220nm and had obvious pH response. The release effect of drug-loaded nanoparticles in acidic conditions is obviously higher than that in neutral and alkaline conditions. In addition

in vitro cytotoxicity experiments showed that the polyamino acid material was not toxic to L-929 cells.

关键词

氨基酸嵌段共聚物纳米载体阿霉素药物释放

Keywords

Amino acidBlock copolymerNano-carrierDoxorubicinDrug release

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