Controlled release hydrogel was an ideal delivery carrier. In order to achieve controlled release of riboflavin in intestinal tract

in this work

sanxan microcapsules was prepared using an extrusion dripping method based on the pH-responsiveness of sanxan. Physical and

in vitro

release properties of sanxan microcapsules was measured

where riboflavin was used as loading drug and calcium chloride as regulatory factor. The results showed that stable sanxan hydrogel was prepared by 0.06 mol/L HCl fixed solution and 0.3% sanxan solution

and the toughness of microcapsules increased but the elasticity decreased after calcium chloride was added. There was no significant change in the release rate of sanxan microcapsules in duodenum

and the release rate of jejunum decreased from 42.5% to 24.1%

when the addition of calcium chloride increased from 0% to 10%. Ileum release occurred when calcium chloride supplemental level was 2% or above

and the release rate gradually decreased from 21.6% to 14.9%. The viscosity characteristics and SEM image analysis showed that the viscosity of sanxan solution increased and the porosity of microcapsules was reduced with calcium chloride added

which was the main reason to control the release of riboflavin. Controlled release of riboflavin in intestinal tract was achieved by adjusting the addition amount of calcium chloride in sanxan microcapsules

indicating that controlled release of sanxan microcapsules has broad application prospects for oral delivery.