Research Progress on <italic style="font-style: italic">in vivo</italic> Degradation and Metabolism Assessment of Carboxymethyl Chitosan-based Biomaterials

WU Li-hao; CHEN Gong; REN Kang; XU Ling

doi:10.14028/j.cnki.1003-3726.2023.02.002

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Research Progress on in vivo Degradation and Metabolism Assessment of Carboxymethyl Chitosan-based Biomaterials

更新时间：2022-12-29

- Research Progress on in vivo Degradation and Metabolism Assessment of Carboxymethyl Chitosan-based Biomaterials
- Polymer Bulletin Vol. 36, Issue 2, Pages: 148-157(2023)
- 作者机构：
  
  厦门大学　公共卫生学院　分子疫苗学与分子诊断学国家重点实验室，厦门　361102
- 作者简介：
- 基金信息：
- DOI：10.14028/j.cnki.1003-3726.2023.02.002
  CLC：
- Published：20 February 2023，
  
  Received：15 April 2022，
  
  Revised：31 May 2022，
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WU Li-hao, CHEN Gong, REN Kang, XU Ling. Research Progress on in vivo Degradation and Metabolism Assessment of Carboxymethyl Chitosan-based Biomaterials. [J]. Polymer Bulletin 36(2):148-157(2023)
DOI：

WU Li-hao, CHEN Gong, REN Kang, XU Ling. Research Progress on in vivo Degradation and Metabolism Assessment of Carboxymethyl Chitosan-based Biomaterials. [J]. Polymer Bulletin 36(2):148-157(2023) DOI： 10.14028/j.cnki.1003-3726.2023.02.002.

摘要

作为一种水溶性多糖高分子材料

羧甲基壳聚糖 (carboxymethyl chitosan

CMCTs) 具有优异的生物相容性和生物降解性以及保湿、止血、抗菌、可吸收等一系列优良的功能特性

因而被广泛应用于医工交叉领域。羧甲基壳聚糖进入体内后

在酶、氧、微生物、水等环境适宜时能够被降解

并经吸收、代谢、排泄。其体内降解速率主要取决于材料的尺寸、脱乙酰度、取代度、分子量等。了解羧甲基壳聚糖在动物体内的降解代谢行为

对羧甲基壳聚糖在转化过程中的质量控制和临床应用至关重要。然而就目前而言

羧甲基壳聚糖在生物体内降解代谢的影响因素及其体内吸收、分布、代谢、排泄规律缺乏系统性总结

这一现状从基础层面严重制约了其在生物医药领域的进一步发展。基于上述问题

本文对近年来羧甲基壳聚糖基生物医用材料的降解、代谢相关研究进行梳理和总结

重点阐述了羧甲基壳聚糖作为可降解材料的生物学特性、降解方式、代谢过程等

系统揭示羧甲基壳聚糖体内降解、代谢的规律

并对植入物尺寸、脱乙酰度、取代度、分子量、交联度及成分比例等影响羧甲基壳聚糖降解速率的主要因素进行归纳

以期为羧甲基壳聚糖基生物医用材料的研发和转化研究提供参考。

Abstract

As a water-soluble polymeric material based on a polysaccharide

carboxymethyl chitosan (CMCTs) has been widely used in the fields of medicine and industry in virtue of their excellent properties such as biocompatibility

biodegradability

moisturizing

hemostasis

antibacterial and absorbability. After being implanted

CMCTs could be degraded while involved in enzyme

oxygen

microbial

water and other suitable environments through absorption

metabolism and excretion. The rate of

in vivo

degradation mainly depends on the size

degree of deacetylation

degree of substitution and molecular weight of the sample. Exploring the degradation and metabolism behavior of CMCTs

in vivo

was essential for the quality control and clinical application of CMCTs. Up to now

the mechanism of the degradation and metabolism of CMCTs in organs in terms of its absorption

distribution

metabolism and excretion patterns

in vivo

is not well elucidated

which would limit its application in the field of biomaterials. Therefore

this review aims to summarize the degradation and metabolism behavior of CMCTs based biomaterials reported in recent years. The biological properties

degradation mode and metabolic process of CMCTs were reviewed. The

in vivo

distribution of metabolism and pathway of excretion during the degradation of CMCTs were interpreted. Meanwhile

the key factors

such as size of implants

degree of deacetylation

degree of substitution

molecular weight

degree of crosslinking and composition

which influence the degradation of CMCTs were also summarized. This work is expected to provide a reference for the research and development of CMCTs based biomaterials.

关键词

壳聚糖羧甲基壳聚糖可吸收植入物降解代谢

Keywords

ChitosanCarboxymethyl chitosanAbsorbable implantsDegradationMetabolism

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厦门大学公共卫生学院分子疫苗学与分子诊断学国家重点实验室

College of Chemistry and Chemical Engineering, Lanzhou University

School of Life Science and Chemistry , Tianshui Normal University

Fujian Key Laboratory of Novel Functional Textile Fibers and Materials, Minjiang University

Fujian Jinhuang Environmental Protection Technology Co.,Ltd.

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Research Progress on in vivo Degradation and Metabolism Assessment of Carboxymethyl Chitosan-based Biomaterials

DOI：10.14028/j.cnki.1003-3726.2023.02.002

摘要

Abstract

关键词

Keywords

references