The Macromolecular Mechanism in the Coagulation Cascade

GUO Xiao-jie; ZHU Dan; SHEN Jian

doi:10.14028/j.cnki.1003-3726.2023.04.010

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The Macromolecular Mechanism in the Coagulation Cascade

更新时间：2023-02-18

- The Macromolecular Mechanism in the Coagulation Cascade
- Polymer Bulletin Vol. 36, Issue 4, Pages: 514-520(2023)
- 作者机构：
  
  南京师范大学化学与材料科学学院，生物医药功能材料国家地方联合工程研究中心，南京　210023
- 作者简介：
- 基金信息：
- DOI：10.14028/j.cnki.1003-3726.2023.04.010
  CLC：
- Published：20 April 2023，
  
  Received：02 August 2022，
  
  Revised：29 August 2022，
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GUO Xiao-jie, ZHU Dan, SHEN Jian. The Macromolecular Mechanism in the Coagulation Cascade. [J]. Polymer Bulletin 36(4):514-520(2023)
DOI：

GUO Xiao-jie, ZHU Dan, SHEN Jian. The Macromolecular Mechanism in the Coagulation Cascade. [J]. Polymer Bulletin 36(4):514-520(2023) DOI： 10.14028/j.cnki.1003-3726.2023.04.010.

摘要

凝血是常见的生理和病理现象。凝血的发生是一系列级联的化学反应，首先是凝血因子在内在或外来因素的触发下产生凝血酶原的激活物，使得凝血酶原转化为凝血酶，纤维蛋白原在凝血酶的作用下，脱去多肽链段转化为纤维蛋白单体，与相邻单体聚合形成纤维蛋白聚合物，最终与血液环境中的血小板、红细胞和内皮细胞等形成网络结构血凝块。本文从大分子化学和物理角度，分析了凝血过程中凝血酶、纤维蛋白的大分子反应和结构变化。

Abstract

Coagulation is a commonly physiological and pathological phenomenon. The occurrence of coagulation is a cascade of chemical reactions. Firstly

the coagulation factors generate the activator of prothrombin under the trigger of internal or external stimuli

so that the prothrombin is converted into thrombin. Secondly

the polypeptide chain is removed from fibrinogen with the activation of thrombin and fibrinogen is converted into the monomers of fibrin

which are polymerized to form the polymer of fibrin. Thirdly

fibrin combines with platelets

red blood cells

and endothelial cells in the blood and finally they form a network of blood clot. In this study

the molecular reactions and the structural changes of thrombin and fibrin in the coagulation have been analyzed from the perspective of macromolecular chemistry and physics.

关键词

凝血生物大分子凝血酶纤维蛋白高分子化学

Keywords

CoagulationBiomacromoleculesThrombinFibrinPolymer chemistry

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