Application of Molecularly Imprinted Polymers in the Diagnosis and Treatment of Malignant Tumors

LI Shi-hong; JIN Yu-shun; WEN Zhen-guo; LIU Ruo-fan; WU Yi-bo

doi:10.14028/j.cnki.1003-3726.2023.05.001

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Application of Molecularly Imprinted Polymers in the Diagnosis and Treatment of Malignant Tumors

更新时间：2023-03-06

- Application of Molecularly Imprinted Polymers in the Diagnosis and Treatment of Malignant Tumors
- Polymer Bulletin Vol. 36, Issue 5, Pages: 539-550(2023)
- 作者机构：
  
  北京石油化工学院　新材料与化工学院　特种弹性体复合材料北京市重点实验室，北京　102617
- 作者简介：
- 基金信息：
- DOI：10.14028/j.cnki.1003-3726.2023.05.001
  CLC：
- Published：20 May 2023，
  
  Received：28 July 2022，
  
  Revised：27 October 2022，
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LI Shi-hong, JIN Yu-shun, WEN Zhen-guo, LIU Ruo-fan, WU Yi-bo. Application of Molecularly Imprinted Polymers in the Diagnosis and Treatment of Malignant Tumors. [J]. Polymer Bulletin 36(5):539-550(2023)
DOI：

LI Shi-hong, JIN Yu-shun, WEN Zhen-guo, LIU Ruo-fan, WU Yi-bo. Application of Molecularly Imprinted Polymers in the Diagnosis and Treatment of Malignant Tumors. [J]. Polymer Bulletin 36(5):539-550(2023) DOI： 10.14028/j.cnki.1003-3726.2023.05.001.

摘要

近年来

癌症的发病率和致死率依然处于不断上升的状态

癌症已经成为威胁全球人类健康的最主要疾病之一。癌症的诊断和治疗往往因无法特异性靶向肿瘤细胞而受到阻碍

分子印迹聚合物是一种合成受体

具有针对目标分子量身定制的识别位点

因此分子印迹聚合物可以对肿瘤细胞进行选择性识别。目前

分子印迹聚合物被广泛应用于制备负载抗癌药物的载体材料方面

成为一种诊疗一体化的特异性靶向恶性肿瘤的工具。本文综述了分子印迹聚合物在恶性肿瘤诊断和治疗方面的应用(包括以抗癌药物为模板、以可以靶向肿瘤标志物的表位为模板、以抗癌药物和可以靶向肿瘤标志物的表位为双模板以及以蛋白质分子建模为模板制备的分子印迹聚合物)。另外

分子印迹聚合物还可以通过阻断人类表皮生长因子受体-2(HER2)的信号通路来抑制乳腺癌的生长。最后

强调了分子印迹聚合物在恶性肿瘤应用的当前挑战和未来前景。

Abstract

The incidence and mortality of cancer kept rising for years. Cancer has become one of the most serious diseases threatening human health in the world. Due to the difficulty of precisely targeting the tumor cells

diagnosis and treatment of cancer is always a problem. Molecularly imprinted polymer (MIP) is a kind of synthetic receptor with tailored recognizable sites on its molecule. It provides a way to selectively recognize tumor cells. Presently

molecular imprinted polymers are widely used in the preparation of anticancer drug carrier materials. It has become a specific targeting tool for the diagnosis and treatment of cancer. The application of molecular imprinted polymer in the diagnosis and treatment of malignant tumors (including using anticancer drugs as the templates

and templates based on a protein molecule modeling) was reviewed in this paper. In addition

molecular imprinted polymers also inhibit breast cancer growth by blocking the human epidermal growth factor receptor-2 (HER2) transducing pathway. The current challenges and future prospects of molecular imprinted polymer application in cancer therapy are also discussed.

关键词

恶性肿瘤分子印迹聚合物肿瘤标志物抗癌药物诊疗一体化

Keywords

Malignant tumorMolecularly imprinted polymerTumor markersAnti-cancer drugsDiagnosis and treatment integration

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