Research Progress of Stimulus-responsive Hydrogels in Cancer Treatment

ZHANG Pan; LV Fu-jie; FAN Zhi-ping; CHENG Ping; HAN Jun

doi:10.14028/j.cnki.1003-3726.2023.05.002

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Research Progress of Stimulus-responsive Hydrogels in Cancer Treatment

更新时间：2023-03-06

- Research Progress of Stimulus-responsive Hydrogels in Cancer Treatment
- Polymer Bulletin Vol. 36, Issue 5, Pages: 551-563(2023)
- 作者机构：
  
  1.聊城大学生物制药研究院，聊城　252059
  2.山东省聊城市中医医院，聊城　252059
  3.聊城高新生物技术有限公司，聊城　252059
- 作者简介：
- 基金信息：
- DOI：10.14028/j.cnki.1003-3726.2023.05.002
  CLC：
- Published：20 May 2023，
  
  Received：08 August 2022，
  
  Revised：21 September 2022，
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ZHANG Pan, LV Fu-jie, FAN Zhi-ping, CHENG Ping, HAN Jun. Research Progress of Stimulus-responsive Hydrogels in Cancer Treatment. [J]. Polymer Bulletin 36(5):551-563(2023)
DOI：

ZHANG Pan, LV Fu-jie, FAN Zhi-ping, CHENG Ping, HAN Jun. Research Progress of Stimulus-responsive Hydrogels in Cancer Treatment. [J]. Polymer Bulletin 36(5):551-563(2023) DOI： 10.14028/j.cnki.1003-3726.2023.05.002.

摘要

恶性肿瘤的治疗在临床中一直备受关注

由于肿瘤细胞的浸润性和顽固性

常规治疗通常会产生严重的毒副作用。相较于全身化疗

局部载药水凝胶的使用显著降低了全身毒性并可实现药物在肿瘤部位的持续递送。此外

经物理掺杂或化学修饰的刺激响应性水凝胶

还可响应环境条件变化(如温度、pH、光等)

实现原位交联和药物可控释放

大大提高了临床顺应性和药物递送效率。本综述分类讨论了用于肿瘤治疗的刺激响应性水凝胶的设计策略;汇总了近年来此类水凝胶的研究进展及其药物递送方案;并针对该领域存在的实际问题提出了可能的发展方向。

Abstract

The treatment of malignant tumor has always attracted much attention in clinical practice. Due to the invasiveness and recalcitrance of tumor cells

conventional treatment schedules generally produce serious toxic side effects. Compared with systemic chemotherapy

the administration of local medical-loaded gels significantly reduces systemic toxicity and enables sustained drug delivery at the tumor site. In addition

stimulation-responsive hydrogels with physical doping or chemical modification can respond to changes in environmental conditions (

e.g.

temperature

light)

achieve gelation

in situ

and controlled drug release

which greatly enhances clinical compliance and efficiency of drug delivery. In this review

we classified and discussed the design strategies of stimulation-responsive hydrogels and summarized the research progress of such hydrogels for tumor treatment in recent years and their drug delivery schemes. Finally

the possible development direction of this field is proposed according to some existing problems.

关键词

刺激响应性水凝胶刺激响应性水凝胶药物控释药物递送系统抗肿瘤

Keywords

Stimulus-responsive hydrogelsStimulus responsiveHydrogelsDrug controlled releaseDrug delivery systemsAntitumor

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